Evidence map›Paper›PMID 36753992›Full record

ArticleESMO open2023

Cancer burden in adolescents and young adults in Europe.

A Trama, D Stark, I Bozovic-Spasojevic, N Gaspar, F Peccatori, A Toss, A Bernasconi, P Quarello, K Scheinemann, S Jezdic and 5 more

Open access · goldAbstract read
In one paragraph

Article in ESMO open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
39.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Burden of early-onset laryngeal cancer in individuals aged 15-49 years: global, regional, and national estimates from the GBD 2021 study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  4. Article
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  6. Sociodemographic Factors related to Financial Toxicity among Cancer Patients and Survivors:"The Second Cancer Patient Experience Survey" - A Nationwide Study in Japan.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  7. Exploring the use of a youth specific screening tool in hematological cancer care: perspectives from young adult patients and healthcare professionals.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  8. Parity as a Risk Factor for Differentiated Thyroid Carcinoma: A Population-based Study.The Journal of clinical endocrinology and metabolism · 2026
    Article
  9. Article
  10. Management of late toxicities and specific follow-up needs of adolescent and young adult cancer survivors: recommendations from scientific societies in Spain.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Long-term health-related quality of life among adolescent and young adult breast cancer survivors.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
  20. Facing the cancer-related life threat as adolescent and young adult (AYA) after initial diagnosis: A qualitative interview study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 13 institutions in 9 countries.

A TramaResearch Department, Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. Electronic address: education@esmo.org.
D StarkLeeds Institute of Medical Research, School of Medicine University of Leeds, Leeds, UK.
I Bozovic-SpasojevicMedical Oncology Department, Institute for Oncology and Radiology of Serbia, Belgrade, Republic of Serbia.
N GasparDepartment of Oncology for Child and Adolescent, Gustave Roussy Cancer Campus, Villejuif, France.
F PeccatoriGynecologic Oncology Department, European Institute of Oncology IRCCS, Milan, Italy.
A TossDepartment of Oncology and Hematology, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.
A BernasconiResearch Department, Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
P QuarelloPediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children's Hospital, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, Torino, Italy; University of Torino, Torino, Italy.
K ScheinemannDivision of Oncology-Hematology, Department of Pediatrics, Kantonsspital Aarau, Aarau, Switzerland; Department of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland; Department of Pediatrics, McMaster Children's Hospital and McMaster University, Hamilton, Canada.
S JezdicScientific and Medical Division, European Society for Medical Oncology (ESMO), Lugano, Switzerland.
A BlondeelDepartment of Scientific Programme Coordination, European Society for Paediatric Oncology (SIOP Europe), Brussels, Belgium.
G Mountzios2nd Department of Medical Oncology and Clinical Trial Unit, Henry Dunant Hospital, Athens, Greece.
S BielackZentrum für Kinder, Jugend und Frauenmedizin Pädiatrie 5, Klinikum Stuttgart-Olgahospital, Stuttgart, Germany.
E SaloustrosDepartment of Oncology, University Hospital of Larissa, Larissa, Greece.
A FerrariPediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Fondazione IRCCS Istituto Nazionale dei Tumori · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITAzienda Ospedaliero-Universitaria di Modena · ITEuropean Institute of Oncology · ITEuropean Society for Medical Oncology · CHEuropean Society for Paediatric Oncology · BEHenry Dunant Hospital · GRInstitut Gustave Roussy · FROlgahospital · DEOncology Institute of Vojvodina · RSUniversity Hospital of Larissa · GRUniversity of Leeds · GBUniversity of Lucerne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer epidemiology is unique in adolescents and young adults (AYAs; aged 15-39 years). The European Society for Medical Oncology/European Society for Paediatric Oncology (ESMO/SIOPE) AYA Working Group aims to describe the burden of cancers in AYAs in Europe and across European Union (EU) countries. PATIENTS AND

methodsWe used data available on the Global Cancer Observatory. We retrieved crude and age-standardised (World Standard Population) incidence and mortality rates. We reported about AYA cancer burden in Europe and between 28 EU member states. We described incidence and mortality for all cancers and for the 13 cancers most relevant to the AYA population.

resultsIncidence and mortality varied widely between countries with the highest mortality observed in Eastern EU countries. Cancers of the female breast, thyroid and male testis were the most common cancers across countries followed by melanoma of skin and cancers of the cervix. Variations in cancer incidence rates across different populations may reflect different distribution of risk factors, variations in the implementation or uptake of screening as well as overdiagnosis. AYA cancer mortality disparities may be due to variation in early-stage diagnoses, different public education and awareness of cancer symptoms, different degrees of access or availability of treatment.

conclusionsOur results highlight the future health care needs and requirements for AYA-specialised services to ensure a homogeneous treatment across different countries as well as the urgency for preventive initiatives that can mitigate the increasing burden.

Indexed as

Delivery of Health CareMelanomaAdolescentChildEuropeFemaleHumansIncidenceMaleMedical OncologyYoung Adultadolescents and young adultscancerincidencemortalitypopulation-based cancer registry

Identifiers

PMID36753992
PMCPMC10024081
OpenAlexW4319301760

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.