Evidence map›Paper›PMID 36753871›Full record

ArticleMaturitas2023

Frequency and type of premature or early menopause in a geographically defined American population.

Walter A Rocca, Liliana Gazzuola Rocca, Carin Y Smith, Ekta Kapoor, Stephanie S Faubion, Elizabeth A Stewart

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Maturitas, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. One size does not fit all: how type of menopause and hormone therapy matters for brain health.The British journal of psychiatry : the journal of mental science · 2025
    Review
  8. Bilateral Oophorectomy Prevalence Among U.S. Women.Journal of women's health (2002) · 2024
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Walter A RoccaDivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Women's Health Research Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. Electronic address: rocca@mayo.edu.
Liliana Gazzuola RoccaDivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. Electronic address: Gazzuola_Rocca.Liliana@mayo.edu.
Carin Y SmithDivision of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. Electronic address: Smith.Carin@mayo.edu.
Ekta KapoorWomen's Health Research Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Division of General Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Center for Women's Health, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. Electronic address: Kapoor.Ekta@mayo.edu.
Stephanie S FaubionCenter for Women's Health, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Division of General Internal Medicine, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, United States. Electronic address: Faubion.Stephanie@mayo.edu.
Elizabeth A StewartWomen's Health Research Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Department of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. Electronic address: Stewart.Elizabeth@mayo.edu.
Mayo Clinic · USMayo Clinic in Florida · US

Funding

Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's DiseaseU54AG044170 · NIA · MAYO CLINIC ROCHESTER · PI KAPOOR, EKTA · 2018 to 2022
$7.7M
Sex-specific Risk for Vascular Dysfunction and Cognitive DeclineP50AG044170 · NIA · MAYO CLINIC ROCHESTER · PI MILLER, VIRGINIA M · 2012 to 2017
$6.1M
Reproductive risk factors for Alzheimer's disease dementia and pathologyRF1AG055151 · NIA · MAYO CLINIC ROCHESTER · PI MIELKE, MICHELLE M, ROCCA, WALTER A · 2017 to 2017
$4.0M
REST/NRSF, miRNAs, and tissue remodeling in adenomyosis pathophysiologyR01HD105714 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CHENNATHUKUZHI, VARGHEESE MANI, NOTHNICK, WARREN B · 2021 to 2025
$3.1M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4M
AHRQ HHS P50 HS023418NIA NIH HHS P50 AG044170NIA NIH HHS R33 AG058738NIA NIH HHS RF1 AG055151NIA NIH HHS U54 AG044170NICHD NIH HHS R01 HD105714
6 · The paper itself

Abstract

objectiveThere is limited information on the prevalence of premature and early menopause. Therefore, we studied the frequency and type of premature (age < 40 years) or early (age 40-44 years) menopause in a geographically-defined American population.

methodsWe studied a random sample of women aged 18 to 50 years who resided in Olmsted County, MN between 1988 and 2007. Women were followed through December 2021, and age at cessation of menses was assessed via review of the medical records included in a medical records-linkage system. Menopause was defined as cessation of menses due to spontaneous or induced ovarian insufficiency.

results1015 women (71.3 %) underwent spontaneous menopause, 138 (9.7 %) underwent bilateral oophorectomy, 17 (1.2 %) had antecedent chemotherapy or radiation therapy, and 254 (17.8 %) underwent hysterectomy or endometrial ablation. The median age at cessation of menses was 51.0 years (IQR, 49.0-52.0) for spontaneous menopause, 46.0 years (IQR, 41.0-49.0) for menopause induced by oophorectomy, chemotherapy, or radiation therapy, and 38.0 years (IQR, 33.0-44.0) for hysterectomy. Considering both spontaneous and induced menopause, the frequency was 3.1 % (95 % CI, 2.2-4.2) for premature and 6.2 % (95 % CI, 5.0-7.8) for early menopause. Considering only spontaneous menopause, the frequency reduced to 0.4 % (95 % CI, 0.2-1.0) for premature and 5.2 % (95 % CI, 4.0-6.8) for early menopause. However, considering all types of cessations of menses, the frequency was 12.2 % (95 % CI, 10.6-14.0) for premature and 9.7 % (95 % CI, 8.3-11.3) for early cessation of menses. DISCUSSION: Approximately 3 % of women in the general population experienced either spontaneous or induced premature menopause. The most common cause of premature menopause was bilateral oophorectomy.

Indexed as

Menopause, PrematurePrimary Ovarian InsufficiencyFemaleHumansMenopauseMinnesotaOvariectomyRisk FactorsAge at menopauseBilateral oophorectomyCessation of mensesEarly menopause, premature ovarian insufficiencyHysterectomyPremature menopause

Identifiers

PMID36753871
PMCPMC9996690
OpenAlexW4319301121

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.