Evidence map›Paper›PMID 36753746›Full record

ArticleThe Journal of urology2023

Use of Monitoring Tests Among Patients With Localized Prostate Cancer Managed With Observation.

Michael S Leapman, Rong Wang, Stacy Loeb, Tyler M Seibert, Franklin D Gaylis, Ben Lowentritt, Gordon A Brown, Ronald Chen, Daniel Lin, John Witte and 4 more

Abstract read
In one paragraph

Article in The Journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Sociodemographic disparities in prostate cancer imaging.Abdominal radiology (New York) · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 12 institutions in 3 countries.

Michael S LeapmanDepartment of Urology, Yale School of Medicine, New Haven, Connecticut.
Rong WangYale Cancer Outcomes, Public Policy, and Effectiveness Research Center, New Haven, Connecticut.
Stacy LoebDepartments of Urology and Population Health, New York University Langone Health, New York, New York.
Tyler M SeibertDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California.
Franklin D GaylisGenesis Healthcare, San Diego, California.
Ben LowentrittChesapeake Urology, Baltimore, Maryland.
Gordon A BrownNew Jersey Urology, Bloomfield, New Jersey.
Ronald ChenDepartment of Radiation Oncology, University of Kansas Medical Center, Kansas City, Kansas.
Daniel LinDepartment of Urology, University of Washington, Seattle, Washington.
John WitteDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, California.
Matthew R CooperbergDepartment of Urology, University of California San Francisco, San Francisco, California.
William J CatalonaDepartment of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Cary P GrossYale Cancer Outcomes, Public Policy, and Effectiveness Research Center, New Haven, Connecticut.
Xiaomei MaYale Cancer Outcomes, Public Policy, and Effectiveness Research Center, New Haven, Connecticut.
Yale Cancer Center · USChesapeake Urology Associates · USFred Hutch Cancer Center · USGenesis Healthcare · USLa Jolla Bioengineering Institute · USNew Jersey Urology · USNorthwestern University · USNYU Langone Health · USStanford University · USUniversity of California, San Francisco · USUniversity of Kansas Medical Center · USYale University · US

Funding

Targeting FOXA1-downstream pathways: a novel therapeutic strategy for castration-resistant prostate cancerP50CA180995 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ABDULKADIR, SARKI A. · 2015 to 2025
$19.9M
Understanding the Adoption and Impact of New Risk Assessment Technologies in Prostate Cancer CareK08CA237872 · NCI · YALE UNIVERSITY · PI LEAPMAN, MICHAEL STUART · 2019 to 2023
$1.1M
NCI NIH HHS K08 CA237872NCI NIH HHS P50 CA180995
6 · The paper itself

Abstract

purposeIt is unknown whether compliance with recommended monitoring tests during observation of localized prostate cancer has changed over time. MATERIALS AND

methodsWe performed a retrospective cohort study of Medicare beneficiaries diagnosed with low- or intermediate-risk prostate cancer in 2004-2016 who were initially managed with observation for a minimum of 12 months. The primary objective was to examine rates of PSA testing, prostate biopsy, and prostate MRI. We used multivariable mixed effects Poisson regression to determine whether rates of PSA testing and prostate biopsy increased over time. In addition, we identified clinical, sociodemographic, and provider factors associated with the frequency of monitoring tests during observation.

resultsWe identified 10,639 patients diagnosed at a median age of 73 (IQR 69-77) years. The median follow-up time was 4.3 (IQR 2.7-6.6) years after diagnosis. Among patients managed without treatment for 5 years, 98% received at ≥1 PSA test, 48.0% ≥1 additional prostate biopsy, and 31.0% ≥1 prostate MRI. Among patients managed with observation for ≥12 months, mixed effects Poisson regression revealed that rates of PSA testing and biopsy increased over time (per calendar year: RR 1.02, 95% CI: 1.02-1.03 and RR 1.10, 95% CI: 1.08-1.11, respectively). Clinical and sociodemographic factors including age, clinical risk, race/ethnicity, census tract poverty, and region were associated with rates of biopsy and PSA testing.

conclusionsUse of recommended monitoring tests including repeat prostate biopsy remains low among Medicare beneficiaries undergoing observation for low- and intermediate-risk prostate cancer.

Indexed as

Prostate-Specific AntigenProstatic NeoplasmsAgedHumansMaleMedicareProstateRetrospective StudiesUnited StatesProstate-Specific Antigenbiopsyprostate-specific antigenprostatic neoplasmswatchful waiting

Identifiers

PMID36753746
PMCPMC13616421
OpenAlexW4319459789

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.