Evidence map›Paper›PMID 36753630›Full record

ArticleThe Journal of urology2023

Utility of Magnetic Resonance Imaging for Localizing Prostate Cancer Near the Urethra in Men Who Are Candidates for Focal Gland Ablation.

Neal Patel, Alexa Hughes, Jj H Zhang, Wayne Brisbane, Ali Rastegarpour, Sohrab Afsahir, Lorna Kwan, Anissa V Nguyen, Anthony Sisk, Steve Raman and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Neal PatelDeparment of Urology, Weill Cornell Medicine, New York, New York.
Alexa HughesDepartment of Urology, University of California, Los Angeles, California.
Jj H ZhangDepartment of Urology, University of California, Los Angeles, California.
Wayne BrisbaneDeparment of Urology, University of Florida, Gainesville, Florida.
Ali RastegarpourDepartment of Radiology, University of California, Los Angeles, California.
Sohrab AfsahirDepartment of Radiology, University of California, Los Angeles, California.
Lorna KwanDepartment of Urology, University of California, Los Angeles, California.
Anissa V NguyenDepartment of Urology, University of California, Los Angeles, California.
Anthony SiskDepartment of Pathology, University of California, Los Angeles, California.
Steve RamanDepartment of Urology, University of California, Los Angeles, California.
Robert ReiterDepartment of Urology, University of California, Los Angeles, California.
University of California, Los Angeles · USUniversity of California System · USUniversity of Florida · USWeill Cornell Medicine · US

Funding

UCLA SPORE IN PROSTATE CANCERP50CA092131 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REITER, ROBERT E · 2002 to 2023
$42.6M
NCI NIH HHS P50 CA092131
6 · The paper itself

Abstract

purposeGiven that treatment near the urethra is often limited to reduce side effects, in this study we aim to determine whether prostate MRI can accurately identify the distance of prostate cancer to the urethra in a cohort of men who were potential candidates for focal gland ablation. MATERIALS AND

methodsA single-institution analysis was performed of men who underwent MRI, targeted biopsy, and radical prostatectomy from July 2012 to April 2021. Men who were candidates for focal gland ablation were identified. The ability of MRI to identify prostate cancer within 5 mm of the prostatic urethra as confirmed on whole-mount pathology was assessed. Multivariate regression was utilized to determine characteristics associated with prostate cancer within 5 mm of the urethra on whole-mount pathology.

resultsIn 48 out of 67 men (72%), the tumor was within 5 mm of the urethra on whole-mount pathology. MRI was concordant with whole-mount pathology in 49 out of 67 men (73%). The sensitivity of MRI for identifying cancer within 5 mm of the urethra was 77% (65%-89%) and the specificity was 63% (42%-89%). The positive predictive value was 84% (range 73%-95%) and negative predictive value was 52% (32%-73%). In adjusted analysis, PSA density and Prostate Imaging-Reporting and Data System were not significantly associated with having prostate cancer within close proximity of the urethra.

conclusionsA significant number of men who are potential candidates for focal gland ablation have cancer within close proximity to the urethra that could serve as a significant source of in-field recurrence. The sensitivity of MRI for identifying these lesions is 77% and can be used to further improve patient selection for focal gland ablation.

Indexed as

Prostatic NeoplasmsUrethraBiopsyHumansMagnetic Resonance ImagingMaleProstateProstatectomyablation techniquesmagnetic resonance imagingprostatic neoplasms

Identifiers

PMID36753630
PMCPMC12721134
OpenAlexW4319458348

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.