ArticlePloS one2023
Establishment of reference intervals for hematological parameters of adult population in the western region of Saudi Arabia.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Hematological parameters' reference intervals in apparently healthy individuals in Saudi Arabia: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Defining Reference Intervals for Complete Blood Count and Micronutrient Parameters in Urban Bangladeshi Population.Biomolecules · 2026Article
- Observational
- Calculation of reference intervals using an indirect approach from laboratory database.Advances in laboratory medicine · 2026Article
- Establishing reference intervals for 25 common biochemical analytes in Tibetans living at very high altitude.Open medicine (Warsaw, Poland) · 2026Article
- Determination of reference intervals for common liver function tests among healthy adults.Scientific reports · 2025Article
- Establishment of reference interval for hemoglobin A1C and other hemoglobin subfractions for healthy Saudi adults.PloS one · 2024Article
- Derivation of Russian-specific reference intervals for complete blood count, iron markers and related vitamins.PloS one · 2024Article
- Complete Blood Count Reference Intervals for Children Aged Less Than 1 to 12 Years in the Northern Region of Ghana.BioMed research international · 2024Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMost of hematology laboratories in Saudi Arabia utilize the reference intervals (RIs) provided by instrument manufacturers. This study aimed to define RIs of hematological parameters for adult population in the western region of Saudi Arabia and to explore their specific features from an international perspective.
methodThis study was conducted according to the harmonized protocol of IFCC Committee on RIs and Decision Limits. Blood samples collected from 409 healthy Saudi males and females adults were analyzed for complete blood count (CBC) by using Cell-Dyn Sapphire analyzer and for iron profile by using Architect analyzers. The needs for RIs partitioned by sex and age was based on standard deviation ratio (SDR) and/or bias ratio (BR). RIs were derived parametrically with/without application of the latent abnormal values exclusion method (LAVE).
resultsBased on thresholds of SDR≥0.4 and/or BR≥0.57, RIs were partitioned by sex for red-blood cell count, hemoglobin, hematocrit, red cell distribution width, erythrocyte sedimentation rate, iron, transferrin, ferritin, eosinophil, platelet, plateletcrit, etc. Partitioning by age was not necessary for any of the analytes. LAVE procedure caused appreciable changes in RI limits for most erythrocyte and iron parameters but not for leukocyte parameters. Comparable to other non-IFCC studies on CBC RIs, the RBC and hematocrit (Ht) ranges have shifted to a higher side in both genders. After applying the LAVE method, the male and female RIs for Hb were 4.56 to 6.22 ×106/μL and 3.94 to 5.25 ×106/μL respectively while RIs for Ht were 40.2 to 52.0% and 33.6 to 44.5% respectively.
conclusionLAVE method contributed to reducing the influence of latent anemia in deriving RIs for erythrocyte related parameters. Using the up-to-date methods, the RIs of CBC determined specifically for Saudis will help to improve the interpretation of test results in medical decision making.
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