Evidence map›Paper›PMID 36753380›Full record

ArticleMolecular biology of the cell2023

Lithium-induced ciliary lengthening sparks Arp2/3 complex-dependent endocytosis.

Brae M Bigge, Larissa L Dougherty, Prachee Avasthi

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Ciliary-Mediated Mechanotransduction in Skeletal Development and Diseases.Results and problems in cell differentiation · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Brae M BiggeDepartment of Biochemistry and Cell Biology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755.
Larissa L DoughertyDepartment of Biochemistry and Cell Biology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755.
Prachee AvasthiDepartment of Biochemistry and Cell Biology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755.ORCID 0000-0002-1688-722X
Dartmouth College · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2025
$25.9M
CYTOSKELETAL AND SIGNALING MECHANISMS REGULATING CILIARY TRAFFICR35GM128702 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI AVASTHI, PRACHEE · 2018 to 2021
$1.6M
NCI NIH HHS P30 CA023108NIGMS NIH HHS P20 GM113132NIGMS NIH HHS R35 GM128702
6 · The paper itself

Abstract

Ciliary length is highly regulated, but can be disrupted by lithium, which causes ciliary elongation across cell types and organisms. We used the algal system

Indexed as

Actin-Related Protein 2-3 ComplexLithiumCiliaEndocytosisGlycogen Synthase Kinase 3Actin-Related Protein 2-3 ComplexGlycogen Synthase Kinase 3Lithium

Identifiers

PMID36753380
PMCPMC10092651
OpenAlexW4319460369

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.