Evidence map›Paper›PMID 36753317›Full record

ArticleAmerican journal of respiratory cell and molecular biology2023

Human Airway Basal Cells Undergo Reversible Squamous Differentiation and Reshape Innate Immunity.

Yihan Zhang, Katharine Elliot Black, Thien-Khoi N Phung, Sujatha Rajeev Thundivalappil, Tian Lin, Wei Wang, Jie Xu, Cheng Zhang, Lida P Hariri, Allen Lapey and 7 more

Abstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  6. Gain-of-function variants in SMAD4 compromise respiratory epithelial function.The Journal of allergy and clinical immunology · 2025
    Article
  7. Article
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  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. A Hint from Wnt: Squamous Cell Differentiation in the Airways.American journal of respiratory cell and molecular biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Yihan ZhangThe Mucosal Immunology & Biology Research Center.
Katharine Elliot BlackDivision of Pulmonary and Critical Care Medicine, Department of Medicine, and.
Thien-Khoi N PhungDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.
Sujatha Rajeev ThundivalappilThe Mucosal Immunology & Biology Research Center.
Tian LinThe Mucosal Immunology & Biology Research Center.
Wei WangDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts.
Jie XuCenter for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, University of Michigan Medical School, Ann Arbor, Michigan.
Cheng ZhangCenter for Individualized Medicine, Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota.
Lida P HaririDivision of Pulmonary and Critical Care Medicine, Department of Medicine, and.
Allen LapeyDivision of Pediatric Pulmonary Medicine, Massachusetts General Hospital for Children, Boston, Massachusetts.
Hu LiCenter for Individualized Medicine, Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota.
Paul Hubert LerouDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts.
Xingbin AiDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts.
Jianwen QueColumbia Center for Human Development.
Jin-Ah ParkDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.
Bryan P HurleyThe Mucosal Immunology & Biology Research Center.
Hongmei MouThe Mucosal Immunology & Biology Research Center.ORCID 0000-0002-6624-7757

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Training Program in Molecular and Integrative Physiological SciencesT32HL007118 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LU, QUAN · 1985 to 2025
$14.3M
The Role of Hepoxilin A3 in Neutrophil Breach of the Infected Airway MucosaR01AI095338 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HURLEY, BRYAN P · 2012 to 2022
$5.2M
Physics of bronchial epithelial unjammingR01HL148152 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J, PARK, JIN-AH · 2019 to 2022
$2.2M
Age-related mechanisms of T helper 2 memory in the early lungR01HL154549 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI AI, XINGBIN · 2021 to 2024
$2.2M
VEGF/KDR Signaling in Airway Epithelial Regeneration and DiseaseR01HL152293 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2021 to 2024
$2.0M
Modeling the premature airway with neonatal airway basal cellsR21AI156597 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LEROU, PAUL HUBERT · 2021 to 2022
$476k
Targeting Chronic Senescence to Restore Tissue Homeostasis in Myhre syndromeR21AR080778 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI LINDSAY, MARK E, MOU, HONGMEI · 2022 to 2023
$386k
NHLBI NIH HHS R01 HL148152NHLBI NIH HHS R01 HL152293NHLBI NIH HHS R01 HL154549NHLBI NIH HHS T32 HL007118NIAID NIH HHS R01 AI095338NIAID NIH HHS R21 AI156597NIAMS NIH HHS R21 AR080778NIEHS NIH HHS P30 ES000002
6 · The paper itself

Abstract

Histological and lineage immunofluorescence examination revealed that healthy conducting airways of humans and animals harbor sporadic poorly differentiated epithelial patches mostly in the dorsal noncartilage regions that remarkably manifest squamous differentiation.

Indexed as

Carcinoma, Squamous CellRespiratory SystemAnimalsCell DifferentiationEpithelial CellsHumansImmunity, Innateglycolysishuman airway epitheliuminnate immunitysquamous differentiationWNT signaling

Identifiers

PMID36753317
PMCPMC10257070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.