Evidence map›Paper›PMID 36753021›Full record

ReviewScience China. Life sciences2023

Enabling technology and core theory of synthetic biology.

Xian-En Zhang, Chenli Liu, Junbiao Dai, Yingjin Yuan, Caixia Gao, Yan Feng, Bian Wu, Ping Wei, Chun You, Xiaowo Wang and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Science China. Life sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Scaling DNA engineering.Trends in biotechnology · 2025
    Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Recent technology advancements in large-scale DNA assembly.Quantitative biology (Beijing, China) · 2025
    Article
  14. Review
  15. Article
  16. Review
  17. Enhancing glucaric acid production fromApplied and environmental microbiology · 2024
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xian-En ZhangFaculty of Synthetic Biology, Shenzhen Institute of Advanced Technology, Shenzhen, 518055, China. zhangxe@ibp.ac.cn.
Chenli LiuFaculty of Synthetic Biology, Shenzhen Institute of Advanced Technology, Shenzhen, 518055, China. chenli.liu@siat.ac.cn.
Junbiao DaiFaculty of Synthetic Biology, Shenzhen Institute of Advanced Technology, Shenzhen, 518055, China. junbiao.dai@siat.ac.cn.
Yingjin YuanFrontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China. yjyuan@tju.edu.cn.
Caixia GaoState Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China. cxgao@genetics.ac.cn.
Yan FengState Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, 200240, China. yfeng2009@sjtu.edu.cn.
Bian WuState Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. wub@im.ac.cn.
Ping WeiFaculty of Synthetic Biology, Shenzhen Institute of Advanced Technology, Shenzhen, 518055, China. ping.wei@siat.ac.cn.
Chun YouTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. you_c@tib.cas.cn.
Xiaowo WangMinistry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Bioinformatics Division, Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University, Beijing, 100084, China. xwwang@tsinghua.edu.cn.
Tong SiFaculty of Synthetic Biology, Shenzhen Institute of Advanced Technology, Shenzhen, 518055, China. tong.si@siat.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic biology provides a new paradigm for life science research ("build to learn") and opens the future journey of biotechnology ("build to use"). Here, we discuss advances of various principles and technologies in the mainstream of the enabling technology of synthetic biology, including synthesis and assembly of a genome, DNA storage, gene editing, molecular evolution and de novo design of function proteins, cell and gene circuit engineering, cell-free synthetic biology, artificial intelligence (AI)-aided synthetic biology, as well as biofoundries. We also introduce the concept of quantitative synthetic biology, which is guiding synthetic biology towards increased accuracy and predictability or the real rational design. We conclude that synthetic biology will establish its disciplinary system with the iterative development of enabling technologies and the maturity of the core theory.

Indexed as

Artificial IntelligenceSynthetic BiologyBiotechnologyGene EditingGenomeartificial intelligent (AI)biofoundrycell engineeringchassis cellcomputer-aided designde novo designDNA storagegene circuitgenome synthesis and assemblymolecular evolutionquantitative synthetic biologysynthetic biology

Identifiers

PMID36753021
PMCPMC9907219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.