Evidence map›Paper›PMID 36752999›Full record

ArticleMolecular diversity2023

Ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate in the smiles rearrangement reaction: straightforward synthesis of amino acid derived quinolin-2(1H)-one enamines.

Sirous Haghipour, Morteza Mehrdad, Samanesadat Hosseini, Ali Moazzam, Kourosh Rad-Moghadam, Mohammad Mahdavi

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Article in Molecular diversity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sirous HaghipourDepartment of Chemistry, Faculty of Science, University of Guilan, Rasht, Iran.
Morteza MehrdadDepartment of Chemistry, Faculty of Science, University of Guilan, Rasht, Iran. m-mehrdad@guilan.ac.ir.
Samanesadat HosseiniShahid Beheshti University of Medical Sciences, Tehran, Iran.
Ali MoazzamEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Kourosh Rad-MoghadamDepartment of Chemistry, Faculty of Science, University of Guilan, Rasht, Iran.
Mohammad MahdaviEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. momahdavi@sina.tums.ac.ir.ORCID http://orcid.org/0000-0002-8007-2543

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper describes the development of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate compound as a heterocyclic enols containing a Michael acceptor so that it participates in an Ugi-type multicomponent condensation through a Smiles rearrangement in replacement of acid components. The new four-component containing 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate, aldehyde derivatives, amine derivatives and isocyanides process leads readily and efficiently to heterocyclic enamines. This report is an outstanding strategy for the preparation of new biologically structures containing peptidic or pseudo-peptidic with quinolin-2(1H)-one scaffolds.

Indexed as

Amino AcidsCarboxylic AcidsAldehydesAldehydesAmino AcidsCarboxylic AcidsEnoleIsocyanideUgi

Identifiers

PMID36752999

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.