ArticleAging clinical and experimental research2023
Fragility Score: a REMS-based indicator for the prediction of incident fragility fractures at 5 years.
Article in Aging clinical and experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 39 citations in OpenAlex.
- Effect of a one time guideline based educational video intervention on osteoporosis related knowledge.Archives of orthopaedic and trauma surgery · 2026Trial
- Fracture Risk Stratification by REMS: A 5 Years Prospective Longitudinal Multicentre Study.Calcified tissue international · 2026Observational
- Single-component imaging and ultrasound-based tools for the assessment of fracture risk.Nature reviews. Rheumatology · 2026Review
- Femoral Skeletal Growth in Early Infancy Assessed by Radiofrequency Echographic Multi-Spectrometry.Journal of clinical ultrasound : JCU · 2026Article
- Nails in osteoporosis and bone metabolism: a narrative review of current evidence and future directions.Archives of osteoporosis · 2026Review
- Early Identification of Low Bone Density Risk Using a Radiofrequency Echographic Multi Spectrometry-Based Prediction Model.Life (Basel, Switzerland) · 2026Article
- Fragility Score in Radiographic Axial Spondyloarthritis Assessed with Radiofrequency Echographic Multi-Spectrometry (REMS).Life (Basel, Switzerland) · 2026Article
- "One-stop-shop" medical imaging for osteoporosis and obese patients: a narrative review.Journal of endocrinological investigation · 2026Review
- Demographic determinants of REMS-derived BMD and fragility score.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Longitudinal monitoring of denosumab-associated bone changes by REMS in postmenopausal women with ER-positive breast cancer receiving aromatase inhibitors.Aging clinical and experimental research · 2026Article
- Osteoporosis and Fracture Risk in Ovarian Cancer: Beyond the Oncologic Burden.Diagnostics (Basel, Switzerland) · 2025Review
- Utility of REMS-Derived Fragility Score and Trabecular Bone Score in Evaluating Bone Health in Type 2 Diabetes Mellitus.Diagnostics (Basel, Switzerland) · 2025Article
- Editorial: Is REMS-BMD Truly a Measured Parameter? A Call for Transparency and Technical Clarification.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Clinical application of radiofrequency echographic multi-spectrometry (REMS) for diagnosis and follow-up in several rare bone disorders: a case series.BMC medical imaging · 2025Article
- 10-Year Fracture Risk Assessment with Novel Adjustment (FRAXplus): Type 2 Diabetic Sample-Focused Analysis.Diagnostics (Basel, Switzerland) · 2025Article
- Review
- The skeletal abnormalities and their clinical challenges inJBMR plus · 2025Article
- Utility of the Fragility Score (FS) Determined Through Radiofrequency Ecographic Multi-Spectrometry (REMS) in the Follow-Up of Patients with Axial Spondyloarthritis (AxSpA).Journal of clinical medicine · 2025Article
- Radiofrequency Echographic Multi Spectrometry-A Novel Tool in the Diagnosis of Osteoporosis and Prediction of Fragility Fractures: A Systematic Review.Diagnostics (Basel, Switzerland) · 2025Review
- Challenges in assessing bone health in early infancy: a narrative review of existing technologies.Frontiers in endocrinology · 2025Review
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Authors and funding
16 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccurate estimation of the imminent fragility fracture risk currently represents a challenging task. The novel Fragility Score (FS) parameter, obtained during a Radiofrequency Echographic Multi Spectrometry (REMS) scan of lumbar or femoral regions, has been developed for the non-ionizing estimation of skeletal fragility.
aimsThe aim of this study was to assess the performance of FS in the early identification of patients at risk for incident fragility fractures with respect to bone mineral density (BMD) measurements.
methodsData from 1989 Caucasians of both genders were analysed and the incidence of fractures was assessed during a follow-up period up to 5 years. The diagnostic performance of FS to discriminate between patients with and without incident fragility fracture in comparison to that of the BMD T-scores measured by both Dual X-ray Absorptiometry (DXA) and REMS was assessed through ROC analysis.
resultsConcerning the prediction of generic osteoporotic fractures, FS provided AUC = 0.811 for women and AUC = 0.780 for men, which resulted in AUC = 0.715 and AUC = 0.758, respectively, when adjusted for age and body mass index (BMI). For the prediction of hip fractures, the corresponding values were AUC = 0.780 for women and AUC = 0.809 for men, which became AUC = 0.735 and AUC = 0.758, respectively, after age- and BMI-adjustment. Overall, FS showed the highest prediction ability for any considered fracture type in both genders, resulting always being significantly higher than either T-scores, whose AUC values were in the range 0.472-0.709.
conclusionFS displayed a superior performance in fracture prediction, representing a valuable diagnostic tool to accurately detect a short-term fracture risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.