Evidence map›Paper›PMID 36752937›Full record

ArticleMolecular biotechnology2024

Identification of Pyrazole Derivatives of Usnic Acid as Novel Inhibitor of SARS-CoV-2 Main Protease Through Virtual Screening Approaches.

Miah Roney, Gagandeep Singh, A K M Moyeenul Huq, Md Shaekh Forid, Wan Maznah Binti Wan Ishak, Kamal Rullah, Mohd Fadhlizil Fasihi Mohd Aluwi, Saiful Nizam Tajuddin

Open access · bronzeAbstract read
In one paragraph

Article in Molecular biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Recent Advances in Nitrogen-Containing Heterocyclic Scaffolds as Antiviral Agents.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2024
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. ZnFeScientific reports · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Miah Roney *Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Kuantan, Pahang Darul Makmur, Malaysia.
Gagandeep Singh *Section of Microbiology, Central Ayurveda Research Institute, Jhansi, Uttar Pradesh, India.
A K M Moyeenul HuqBio Aromatic Research Centre, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Kuantan, Pahang Darul Makmur, Malaysia. moyeenul@ump.edu.my.ORCID http://orcid.org/0000-0001-9437-9821
Md Shaekh ForidFaculty of Chemical and Processing Engineering Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Kuantan, Pahang Darul Makmur, Malaysia.
Wan Maznah Binti Wan IshakFaculty of Chemical and Processing Engineering Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Kuantan, Pahang Darul Makmur, Malaysia.
Kamal RullahKulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Jalan Sultan Ahmad Shah, 25200, Kuantan, Pahang, Malaysia.
Mohd Fadhlizil Fasihi Mohd AluwiFaculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Kuantan, Pahang Darul Makmur, Malaysia. fasihi@ump.edu.my.
Saiful Nizam TajuddinFaculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Kuantan, Pahang Darul Makmur, Malaysia.
Universiti Malaysia Pahang Al-Sultan Abdullah · MYCentral Council for Research in Ayurvedic Science · INInternational Islamic University Malaysia · MY

Funding

Lembaga Koko Malaysia RDU 210710
6 · The paper itself

Abstract

The infection produced by the SARS-CoV-2 virus remains a significant health crisis worldwide. The lack of specific medications for COVID-19 necessitates a concerted effort to find the much-desired therapies for this condition. The main protease (M

Indexed as

Antiviral AgentsBenzofuransCoronavirus 3C ProteasesMolecular Docking SimulationMolecular Dynamics SimulationPyrazolesSARS-CoV-2Catalytic DomainCOVID-19COVID-19 Drug TreatmentDrug Evaluation, PreclinicalHumansProtease InhibitorsProtein Binding3C-like proteinase, SARS-CoV-2Antiviral AgentsBenzofuransCoronavirus 3C ProteasesProtease InhibitorsPyrazolesADMETDockingDrug-likenessMolecular dynamics simulationPyrazole derivatives of Usnic acidSARS-CoV-2

Identifiers

PMID36752937
PMCPMC9907211
OpenAlexW4319454815

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.