ArticleCurrent microbiology2023
Glucose-Induced Enhanced Virulence in Strains of Multidrug-Resistant Pseudomonas aeruginosa Isolated from Diabetic Patients.
Article in Current microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Host-derived stimuli alter intracellular calcium levels inApplied and environmental microbiology · 2026Article
- Oral Microbial and Metabolic Alterations in Patients With Oral Lichen Planus Concomitant With Type 2 Diabetes Mellitus.MicrobiologyOpen · 2026Observational
- Exclusion of catabolic regulation B (cbrB) gene in Pseudomonas aeruginosa attenuates the virulence at different glucose concentrations.BMC microbiology · 2026Article
- Overexpression of Agr quorum sensing system in uropathogenic Staphylococcus aureus in response to simulated urinary metabolic conditions enhancing growth and virulence.Medical microbiology and immunology · 2025Article
- Cutaneous Adverse Drug Reactions Associated with SGLT2 Inhibitors.Journal of clinical medicine · 2024Review
- Urinary Tract Infections and Fungal Infections Associated with Sodium-Glucose Co-transporter-2 (SGLT-2) Inhibitors and Metformin Combination: A Real-World Study from 2013 to 2023 Based on the FDA Adverse Event Reporting System (FAERS) Database.Journal of clinical practice and research · 2024Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Pseudomonas aeruginosa is known for its metabolic versatility and uses a variety of substrates; interestingly, glucose is not the favored carbon source. Although glucose is not readily utilized by them, there is a possibility that the increased susceptibility of diabetics to infections with P. aeruginosa is related to the effect of glucose on the expression of virulence genes. The curiosity in understanding the effect of glucose on virulence gene expression in P. aeruginosa and the lacuna of studies in this field prompted us to undertake the current investigation. It included the quantification of various virulence factors and their gene expression upon supplementation with glucose in clinical MDR P. aeruginosa isolates recovered from diabetics. Interestingly, the study observed a remarkable difference in the virulence attributes in the isolates with and without glucose supplementation. External glucose was found to be modulating the QS gene expression, thus altering the elaboration of other virulence factors. Variations in the gene expressions induced by glucose partly explain the increased susceptibility of diabetic patients to P. aeruginosa infections.
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