Evidence map›Paper›PMID 36752885›Full record

ReviewCellular and molecular neurobiology2023

The Role of Non-coding RNAs in Methamphetamine-Induced Neurotoxicity.

Luyao Xu, Lingyue Li, Qianling Chen, Yuebing Huang, Xuebing Chen, Dongfang Qiao

Open access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. An update: epigenetic mechanisms underlying methamphetamine addiction.Frontiers in cell and developmental biology · 2024
    Review
  5. Review
  6. Cognitive Impairment in Multiple Sclerosis.Bioengineering (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Luyao XuDepartment of Forensic Pathology, School of Forensic Medicine, Southern Medical University, South Shaitai Road #1023. 510515, Guangzhou, China.
Lingyue LiDepartment of Forensic Pathology, School of Forensic Medicine, Southern Medical University, South Shaitai Road #1023. 510515, Guangzhou, China.
Qianling ChenDepartment of Forensic Pathology, School of Forensic Medicine, Southern Medical University, South Shaitai Road #1023. 510515, Guangzhou, China.
Yuebing HuangDepartment of Forensic Pathology, School of Forensic Medicine, Southern Medical University, South Shaitai Road #1023. 510515, Guangzhou, China.
Xuebing ChenDepartment of Forensic Pathology, School of Forensic Medicine, Southern Medical University, South Shaitai Road #1023. 510515, Guangzhou, China. csi234@smu.edu.cn.ORCID https://orcid.org/0000-0003-4561-093X
Dongfang QiaoDepartment of Forensic Pathology, School of Forensic Medicine, Southern Medical University, South Shaitai Road #1023. 510515, Guangzhou, China. qiaodf@smu.edu.cn.
Southern Medical University · CN

Funding

Medical Science and Technology Foundation of Guangdong Province B2022019National Natural Science Foundation of China 82271536National Natural Science Foundation of China 82271930Natural Science Foundation of Guangdong Province 2021A1515010909Natural Science Foundation of Guangdong Province 2021A1515110414Postdoctoral Research Foundation of China 2021M701609
6 · The paper itself

Abstract

Methamphetamine (METH) is an amphetamine-type stimulant that is highly toxic to the central nervous system (CNS). Repeated intake of METH can lead to addiction, which has become a globalized problem, resulting in multiple public health and safety problems. Recently, the non-coding RNA (ncRNA) has been certified to play an essential role in METH addiction through various mechanisms. Herein, we mainly focused on three kinds of ncRNAs including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), which are involved in neurotoxicity effects such as cognitive impairment, behavioral abnormalities, and psychiatric disorders due to METH abuse. In addition, differential expression (DE) ncRNAs also suggest that specific responses and sensitivity to METH neurotoxicity exist in different brain regions and cells. We summarized the relationships between the ncRNAs and METH-induced neurotoxicity and psychiatric disturbances, respectively, hoping to provide new perspectives and strategies for the prevention and treatment of METH abuse. Schematic diagram of the non-coding RNAs (ncRNAs) was involved in methamphetamine (METH)-induced neurotoxicity. The ncRNAs were involved in METH-induced blood-brain barrier disruption, neuronal, astrocyte, and microglial damage, and synaptic neurotransmission impairment. The study of ncRNAs is a hot spot in the future to further understand the neurotoxicity of METH and provide more favorable scientific support for clinical diagnosis and innovation of related treatments.

Indexed as

Behavior, AddictiveMethamphetamineMicroRNAsNeurotoxicity SyndromesAmphetamineHumansAmphetamineMethamphetamineMicroRNAsBrain region specificityMethamphetamine (METH)Methamphetamine-related psychiatric disordersNeurotoxicityNon-coding RNA (ncRNA)

Identifiers

PMID36752885
PMCPMC11410138
OpenAlexW4319461676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.