Evidence map›Paper›PMID 36752871›Full record

ArticleAmino acids2023

A search for acrolein scavengers among food components.

Takeshi Uemura, Masashi Uchida, Mizuho Nakamura, Momo Shimekake, Akihiko Sakamoto, Yusuke Terui, Kyohei Higashi, Itsuko Ishii, Keiko Kashiwagi, Kazuei Igarashi

Abstract read
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In one paragraph

Article in Amino acids, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Takeshi UemuraAmine Pharma Research Institute, Innovation Plaza at Chiba University, 1-8-15 Inohana, Chuo-Ku, Chiba, 260-0856, Japan.
Masashi UchidaGraduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Mizuho NakamuraAmine Pharma Research Institute, Innovation Plaza at Chiba University, 1-8-15 Inohana, Chuo-Ku, Chiba, 260-0856, Japan.
Momo ShimekakeFaculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan.
Akihiko SakamotoFaculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, Japan.
Yusuke TeruiFaculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, Japan.
Kyohei HigashiFaculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan.
Itsuko IshiiGraduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Keiko KashiwagiFaculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, Japan.
Kazuei IgarashiAmine Pharma Research Institute, Innovation Plaza at Chiba University, 1-8-15 Inohana, Chuo-Ku, Chiba, 260-0856, Japan. iga16077@gmail.com.
Chiba University · JPChiba Institute of Science · JPTokyo University of Science · JPAmine Pharma (Japan) · JP

Funding

Scientific Research from the Ministry of Education, Cultures, Sports, Science and Technology, Japan 21K06714
6 · The paper itself

Abstract

Brain stroke is a major cause of being bedridden for elderly people, and preventing stroke is important for maintaining quality of life (QOL). Acrolein is a highly reactive aldehyde and causes tissue damage during stroke. Decreasing acrolein toxicity ameliorates tissue injury during brain stroke. In this study, we tried to identify food components which decrease acrolein toxicity. We found that 2-furanmethanethiol, cysteine methyl and ethyl esters, alliin, lysine and taurine decreased acrolein toxicity. These compounds neutralized acrolein by direct interaction. However, the interaction between acrolein and taurine was not so strong. Approximately 30 mM taurine was necessary to interact with 10 μM acrolein, and 2 g/kg taurine was necessary to decrease the size of mouse brain infarction. Taurine also slightly increased polyamine contents, which are involved in decrease in the acrolein toxicity. Mitochondrial potential damage by acrolein was also protected by taurine. Our results indicate that daily intake of foods containing 2-furanmethanethiol, cysteine methyl and ethyl esters, alliin, lysine and taurine may prevent severe injury in brain stroke and improve the quality of life for elderly people.

Indexed as

AcroleinStrokeAnimalsCysteineFuransLysineMiceQuality of LifeSulfhydryl CompoundsAcroleinalliinCysteineFuransfurfuryl mercaptanLysineSulfhydryl CompoundsAcrolein scavengersBrain strokeMitochondriaPolyamineTaurine

Identifiers

PMID36752871
OpenAlexW4319458789

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.