Evidence map›Paper›PMID 36752629›Full record

ArticlemBio2023

Chloride Ions Are Required for Thermosipho africanus MurJ Function.

Sujeet Kumar, Aurelio Mollo, Frederick A Rubino, Daniel Kahne, Natividad Ruiz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sujeet KumarDepartment of Microbiology, The Ohio State University, Columbus, Ohio, USA.
Aurelio MolloDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Frederick A RubinoDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Daniel KahneDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.ORCID 0000-0002-8296-1424
Natividad RuizDepartment of Microbiology, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-6369-2206
Harvard University · USThe Ohio State University · US

Funding

Discovery and characterization of new bacterial cell wall targets and inhibitors to treat resistant infectionsR01AI148752 · NIAID · HARVARD MEDICAL SCHOOL · PI Daniel Kahne, Suzanne Walker · 2020 to 2026
$5.5M
Envelope Biogenesis in Gram-negative BacteriaR01GM100951 · NIGMS · OHIO STATE UNIVERSITY · PI RUIZ, NATIVIDAD · 2012 to 2023
$3.7M
Targeting Membrane Transport Steps in Cell Envelope AssemblyR01AI153358 · NIAID · HARVARD UNIVERSITY · PI KAHNE, DANIEL, KRUSE, ANDREW · 2020 to 2024
$3.6M
NIAID NIH HHS R01 AI148752NIAID NIH HHS R01 AI153358NIGMS NIH HHS R01 GM100951
6 · The paper itself

Abstract

Most bacteria have a peptidoglycan cell wall that determines their cell shape and helps them resist osmotic lysis. Peptidoglycan synthesis depends on the translocation of the lipid-linked precursor lipid II across the cytoplasmic membrane by the MurJ flippase. Structure-function analyses of MurJ from Thermosipho africanus (MurJ

Indexed as

Escherichia coli ProteinsBacteriaCell WallChloridesEscherichia coliLipidsPeptidoglycanPhospholipid Transfer ProteinsChloridesEscherichia coli ProteinsLipidsMurJ protein, E coliPeptidoglycanPhospholipid Transfer Proteinsalternating accesscell wallchloride ioncounterionflippaseglycolipidlipid IIlipid transportmembrane transporterpeptidoglycan

Identifiers

PMID36752629
PMCPMC9973255
OpenAlexW4319460994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.