ArticleApplied and environmental microbiology2023
Systematic Adaptation of Bacillus licheniformis to 2-Phenylethanol Stress.
Article in Applied and environmental microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Systems-level transcriptomic and physiological adaptation of Bacillus licheniformis BLN313 to selenite stress.World journal of microbiology & biotechnology · 2026Article
- Systematic process optimization for enhanced biosynthesis of 2-phenylethanol using Candida sorboxylosa.Bioprocess and biosystems engineering · 2026Article
- Storage stability ofFrontiers in microbiology · 2026Article
- EngineeringFrontiers in microbiology · 2026Review
- Metabolic reprogramming and computation-aided protein engineering for high-level de novo biosynthesis for 2-phenylethanol inSynthetic and systems biotechnology · 2025Article
- Integrated Spectroscopic Analysis of Wild Beers: Molecular Composition and Antioxidant Properties.International journal of molecular sciences · 2025Article
- Overexpressing Endopeptidase Inhibitor IseA Enhances Biomass and Biochemical Production of Bacillus licheniformis.Current microbiology · 2025Article
- Heterologous and High Production of Ergothioneine inMetabolites · 2025Article
- Biotechnological 2-Phenylethanol Production: Recent Developments.Molecules (Basel, Switzerland) · 2024Review
- Metabolic and tolerance engineering of Komagataella phaffii for 2-phenylethanol production through genome-wide scanning.Biotechnology for biofuels and bioproducts · 2024Article
- Analysis of heterologous expression of phaCBA promotes the acetoin stress response mechanism in Bacillus subtilis using transcriptomics and metabolomics approaches.Microbial cell factories · 2024Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The compound 2-phenylethanol (2-PE) is a bulk flavor and fragrance with a rose-like aroma that can be produced by microbial cell factories, but its cellular toxicity inhibits cellular growth and limits strain performance. Specifically, the microbe Bacillus licheniformis has shown a strong tolerance to 2-PE. Understanding these tolerance mechanisms is crucial for achieving the hyperproduction of 2-PE. In this report, the mechanisms of B. licheniformis DW2 resistance to 2-PE were studied by multi-omics technology coupled with physiological and molecular biological approaches. 2-PE induced reactive oxygen species formation and affected nucleic acid, ribosome, and cell wall synthesis. To manage 2-PE stress, the antioxidant and global stress response systems were activated; the repair system of proteins and homeostasis of the ion and osmotic were initiated. Furthermore, the tricarboxylic acid cycle and NADPH synthesis pathways were upregulated; correspondingly, scanning electron microscopy revealed that cell morphology was changed. These results provide deeper insights into the adaptive mechanisms of B. licheniformis to 2-PE and highlight the potential targets for genetic manipulation to enhance 2-PE resistance.
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