ArticleOpen forum infectious diseases2023
Comparing Complication Rates of Midline Catheter vs Peripherally Inserted Central Catheter. A Systematic Review and Meta-analysis.
Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of a Zinc Oxide Adhesive Securement Device in the Fixation of Midline and Peripherally Inserted Central Catheters in Hospitalized Adult Patients: Randomised Clinical Trial
Complication Rates Associated With Central Venous Catheters Versus Midline Catheters: A Randomized Control Trial
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Comparative safety and effectiveness of midline catheters vs. peripherally inserted central catheters: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Pooled it
- Central venous versus short midline catheter in difficult intravenous access patients: a randomised clinical pilot trial.BMJ open · 2026Trial
- Trial
- Impact of limb ischemic preconditioning on the incidence of vein thrombosis in patients with peripherally inserted central catheter.Pathology oncology research : POR · 2024Trial
- Safety and Cost Evaluation of Modified Medium-Length Catheters in Patients With Advanced Cancer: A Randomized Controlled Trial.Journal of nursing care qualityTrial
- Multidisciplinary Advanced Practice Nursing-Led Vascular Access Care Pathway in Patients with Cystic Fibrosis: A Practice-Based Descriptive Analysis.Healthcare (Basel, Switzerland) · 2026Article
- Midline Catheters: A Novel Curriculum for Emergency Medicine Residents.Journal of education & teaching in emergency medicine · 2026Article
- Evaluation of Intravenous Administration of Anti-Infective Agents and Documentation Quality in Orthopedics and Trauma Surgery: A Quantitative Study on Discrepancies Between Physician Prescriptions and Nursing Records.Antibiotics (Basel, Switzerland) · 2026Article
- Catheter-Related Superficial Venous Thrombosis of the Upper Extremity: A Narrative Review of Current Evidence, Diagnostic Pathways, and Management Strategies.Journal of blood medicine · 2026Review
- Clinical Application of Midline Catheters in an Acute Care Ward: A Single-center Retrospective Observational Study.Journal of community hospital internal medicine perspectives · 2026Article
- Nursing care of an elderly patient with toxic epidermal necrolysis: a case report.Frontiers in medicine · 2026Article
- Safety and efficacy of continuous cefazolin infusion via peripheral intravenous catheter (PIVC) for outpatient therapy: a brief report.JAC-antimicrobial resistance · 2025Article
- Perils of the PICC: Peripherally Inserted Central Catheter-Associated Complications and Recommendations for Prevention in Clinical Practice-A Narrative Review.Healthcare (Basel, Switzerland) · 2025Review
- Delivery of Outpatient Parenteral Antimicrobial Therapy (OPAT) in an Ever-Changing National Health Service (UK): Benefits, Barriers, and Opportunities.Antibiotics (Basel, Switzerland) · 2025Review
- Study on PTFE superhydrophobic coating modified by IC@dMSNs and its enhanced antibacterial effect.Journal of advanced research · 2025Article
- Catheter-Related Late Complications in Cancer Patients During and After the COVID-19 Pandemic: A Retrospective Study.Cancers · 2025Article
- A predictive model for catheter-related bloodstream infection in neonates with peripherally inserted central catheter.Frontiers in medicine · 2025Article
- Epidemiology and Clinical Insights of Catheter-Related Candidemia in Non-ICU Patients with Vascular Access Devices.Microorganisms · 2024Article
- Remote Assisted Home Dressing vs. Outpatient Medication of Central Venous Catheter (Peripherally Inserted Central Venous Catheter): Clinical Trial A.R.C.O. (Remote Assistance Oncology Caregiver).Nursing reports (Pavia, Italy) · 2024Article
- Incidence of Catheter-Associated Bloodstream Infections in Stem Cell Recipients-Should We Be "PICCy"?Cancers · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Peripherally inserted central catheters (PICCs) and midlines are commonly used devices for reliable vascular access. Infection and thrombosis are the main adverse effects of these catheters. We aimed to evaluate the relative risk of complications from midlines and PICCs. Methods: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) and observational studies. The primary outcomes were catheter-related bloodstream infection (CRBSI) and thrombosis. Secondary outcomes evaluated included mortality, failure to complete therapy, catheter occlusion, phlebitis, and catheter fracture. The certainty of evidence was assessed using the GRADE approach. Results: Of 8368 citations identified, 20 studies met the eligibility criteria, including 1 RCT and 19 observational studies. Midline use was associated with fewer patients with CRBSI compared with PICCs (odds ratio [OR], 0.24; 95% CI, 0.15-0.38). This association was not observed when we evaluated risk per catheter. No significant association was found between catheters when evaluating risk of localized thrombosis and pulmonary embolism. A subgroup analysis based on location of thrombosis showed higher rates of superficial venous thrombosis in patients using midlines (OR, 2.30; 95% CI, 1.48-3.57). We did not identify any significant difference between midlines and PICCs for the secondary outcomes. Conclusions: Our findings suggest that patients who use midlines might experience fewer CRBSIs than those who use PICCs. However, the use of midline catheters was associated with greater risk of superficial vein thrombosis. These findings can help guide future cost-benefit analyses and direct comparative RCTs to further characterize the efficacy and risks of PICCs vs midline catheters.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.