Evidence map›Paper›PMID 36751276›Full record

ArticleRegenerative therapy2023

Priming with caffeic acid enhances the potential and survival ability of human adipose-derived stem cells to counteract hypoxia.

H M Shifa Ul Haq, Ramla Ashfaq, Azra Mehmood, Warda Shahid, Ghufran Azam, Maryam Azam, Saba Tasneem, Shehla Javed Akram, Kausar Malik, Sheikh Riazuddin

Open access · goldAbstract read
In one paragraph

Article in Regenerative therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Biological and Phytochemical Insights IntoFood science & nutrition · 2025
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

H M Shifa Ul HaqNational Centre of Excellence in Molecular Biology, 87-West Canal Bank Road, University of Punjab, Lahore, 53700, Pakistan.
Ramla AshfaqNational Centre of Excellence in Molecular Biology, 87-West Canal Bank Road, University of Punjab, Lahore, 53700, Pakistan.
Azra MehmoodNational Centre of Excellence in Molecular Biology, 87-West Canal Bank Road, University of Punjab, Lahore, 53700, Pakistan.
Warda ShahidNational Centre of Excellence in Molecular Biology, 87-West Canal Bank Road, University of Punjab, Lahore, 53700, Pakistan.
Ghufran AzamNational Centre of Excellence in Molecular Biology, 87-West Canal Bank Road, University of Punjab, Lahore, 53700, Pakistan.
Maryam AzamNational Centre of Excellence in Molecular Biology, 87-West Canal Bank Road, University of Punjab, Lahore, 53700, Pakistan.
Saba TasneemNational Centre of Excellence in Molecular Biology, 87-West Canal Bank Road, University of Punjab, Lahore, 53700, Pakistan.
Shehla Javed AkramDonValley Pharmaceuticals (Pvt) Ltd. Akram Medical Complex, Lahore.
Kausar MalikNational Centre of Excellence in Molecular Biology, 87-West Canal Bank Road, University of Punjab, Lahore, 53700, Pakistan.
Sheikh RiazuddinNational Centre of Excellence in Molecular Biology, 87-West Canal Bank Road, University of Punjab, Lahore, 53700, Pakistan.
Centre of Excellence in Molecular Biology · PKAllama Iqbal Medical College · PKPakistan Council of Scientific & Industrial Research · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The therapeutic effectiveness of stem cells after transplantation is hampered by the hypoxic milieu of chronic wounds. Prior research has established antioxidant priming as a thorough plan to improve stem cell performance. The purpose of this study was to ascertain how caffeic acid (CA) priming affected the ability of human adipose-derived stem cells (hASCs) to function under hypoxic stress. In order to study the cytoprotective properties of CA, hASCs were primed with CA in CoCl

Indexed as

AntioxidantsCaffeic acidCaffeic acid, (CA)Cobalt chlorideHuman adipose-derived stem cellsHuman adipose-derived stem cells, (hASCs)Hypoxia stressMesenchymal stem cells, (MSCs)oxidative stress, (OS)Pre-conditioningReactive oxygen species, (ROS)Stromal vascular fraction, (SVF)

Identifiers

PMID36751276
PMCPMC9883200
OpenAlexW4317937035

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.