Evidence map›Paper›PMID 36751050›Full record

ArticleJournal of dental research2023

Periderm Fate during Palatogenesis: TGF-β and Periderm Dedifferentiation.

G Saroya, J Hu, M Hu, C Panaretos, J Mann, S Kim, J O Bush, V Kaartinen

Open access · greenAbstract read
In one paragraph

Article in Journal of dental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. [Distribution of ABO and Rh Blood Groups in Tibetan and Han Populations With Cleft Lip and Palate in a Tertiary Hospital in Western China].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Article
  5. [Gene-gene/gene-environment interaction of transforming growth factor-β signaling pathway and the risk of non-syndromic oral clefts].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024
    Article
  6. Neural crest and periderm-specific requirements ofbioRxiv : the preprint server for biology · 2024
    Article
  7. Canonical Wnt signaling is not required forFrontiers in physiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

G SaroyaDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA.ORCID 0000-0002-8041-9586
J HuDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
M HuDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
C PanaretosDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
J MannDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
S KimDepartment of Cell and Tissue Biology and Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA, USA.
J O BushDepartment of Cell and Tissue Biology and Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA, USA.
V KaartinenDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA.ORCID 0000-0002-9432-510X
University of Michigan · USUniversity of California, San Francisco · US

Funding

THE ROLE OF TGF-BETA3 IN PALATOGENESISR01DE013085 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAARTINEN, VESA M · 2001 to 2014
$5.4M
Signaling control and cellular basis of craniofacial morphogenesis and congenital diseaseR35DE031926 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeffrey Ohmann Bush · 2022 to 2026
$5.2M
TGFbeta 3 signaling in palatal periderm degenerationR56DE026464 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAARTINEN, VESA M, NAWSHAD, ALI · 2017 to 2017
$588k
Development of periderm-specific Cre mouse lines to study palatogenesisR03HD100602 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAARTINEN, VESA M · 2020 to 2021
$156k
NICHD NIH HHS R03 HD100602NIDCR NIH HHS R01 DE013085NIDCR NIH HHS R35 DE031926NIDCR NIH HHS R56 DE026464
6 · The paper itself

Abstract

Failure of palatogenesis results in cleft palate, one of the most common congenital disabilities in humans. During the final phases of palatogenesis, the protective function of the peridermal cell layer must be eliminated for the medial edge epithelia to adhere properly, which is a prerequisite for the successful fusion of the secondary palate. However, a deeper understanding of the role and fate of the periderm in palatal adherence and fusion has been hampered due to a lack of appropriate periderm-specific genetic tools to examine this cell type in vivo. Here we used the cytokeratin-6A (Krt-6a) locus to develop both constitutive (

Indexed as

Cleft PalatePalateTransforming Growth Factor betaAnimalsEpithelial CellsHumansMiceReceptor, Transforming Growth Factor-beta Type IReceptor, Transforming Growth Factor-beta Type ITgfbr1 protein, mouseTransforming Growth Factor betacell biologycell differentiationcleft palatecraniofacial biology/geneticsgrowth factor(s)morphogenesis

Identifiers

PMID36751050
PMCPMC10041600
OpenAlexW4319461682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.