ArticleImmunity & ageing : I & A2023
Stratum corneum hydration inversely correlates with certain serum cytokine levels in the elderly, possibly contributing to inflammaging.
Article in Immunity & ageing : I & A, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Gender differences in the relationship between dynapenic abdominal obesity and non-neoplastic digestive system diseases among middle-aged and older adults.BMC gastroenterology · 2026Article
- Low Humidity Alters Epidermal Gene Expression in vivo.Clinical, cosmetic and investigational dermatology · 2026Article
- Influence of Oral Collagen Peptides on Skin Biophysical Properties in Humans: A Narrative Review.Clinical, cosmetic and investigational dermatology · 2026Review
- Skin Protection Effects of Lactobacillus paragasseri HN910 Lysate and the Role of Alanine.Probiotics and antimicrobial proteins · 2026Article
- Isosorbide Diesters: Mechanistic Insights and Therapeutic Applications in Skin and Neuroinflammatory Disorders.International journal of molecular sciences · 2025Review
- Epidermal Penetration Increases with Age and May Contribute to Systemic Inflammation.The Journal of investigative dermatology · 2025Article
- Inflammation and vasopressin hypersecretion in aging.Frontiers in endocrinology · 2025Review
- Comparative Efficacy of Silicone Sheets and Hyperbaric Oxygen Therapy in Post-Surgical Scar Prevention: A Prospective Observational Study.International journal of medical sciences · 2025Observational
- Review
- Stratum corneum hydration levels are negatively correlated with HbA1c levels in the elderly Chinese.Journal of diabetes · 2024Article
- The Psychology of Atopic Dermatitis.Journal of clinical medicine · 2024Review
- Effects of a leave-on product on the strength of the dermoepidermal junction: An exploratory, intraindividual, randomized controlled trial in older adults with dry skin.Health science reports · 2024Article
- Association Between Atopic Dermatitis and Aging: Clinical Observations and Underlying Mechanisms.Journal of inflammation research · 2024Review
- The Skin and Inflamm-Aging.Biology · 2023Review
- Review
- Link between the skin and autism spectrum disorder.Frontiers in psychiatry · 2023Article
- Improvement in Cutaneous Conditions Can Benefit Some Health Conditions in the Elderly.Clinical interventions in aging · 2023Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic, low-grade inflammation, also termed 'inflammaging', has been linked to the development of some aging-associated disorders. Recent studies suggest that inflammaging is attributable to aging-associated epidermal dysfunction. However, abnormality in which epidermal function contributes to inflammaging is not clear.
objectiveWe delineated the correlation of epidermal functions with circulating levels of proinflammatory cytokines in the elderly.
methodsBlood sample was collected from a total of 255 participants aged ≥ 65 years. Epidermal biophysical properties were measured on the left forearm and the right shin. Serum cytokine levels were measured by Multiplex Luminex Assays.
resultsNeither skin surface pH nor transepidermal water loss rates (TEWL) correlated with serum cytokine levels except TEWL on the right shin for TNFa (p < 0.05). In contrast, stratum corneum hydration levels on both the forearm and the shin correlated negatively with serum cytokine levels (p < 0.05).
conclusionReduced stratum corneum hydration likely contributes to inflammaging.
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Registered trials
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