ArticleBMC cancer2023
Mean platelet volume/platelet count ratio in combination with tumor markers in colorectal cancer: a retrospective clinical study.
Article in BMC cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 12 citations in OpenAlex.
- Serological signatures and pathological features for the management of CEA-negative colorectal cancer: development of combined diagnostic and prognostic nomograms.World journal of surgical oncology · 2026Article
- Article
- Validation of Platelet-index based Score (PIBS) for Early Prediction of the Pathological Stage in Colorectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Exploring the link: Hemogram-derived markers in type 2 diabetes mellitus and its complications.World journal of diabetes · 2025Review
- A nomogram based on peripheral blood count between 12 and 18 weeks of gestation for predicting early-onset pre-eclampsia in pregnant women: a retrospective case-control study.BMC pregnancy and childbirth · 2025Article
- Mean Platelet Volume-to-Platelet Count Ratio (MPR) in Acute Exacerbations of Idiopathic Pulmonary Fibrosis: A Novel Biomarker for ICU Mortality.Medicina (Kaunas, Lithuania) · 2025Article
- Establishment and validation of a recurrence risk model in early-stage tongue squamous cell carcinoma patients incorporating immune-inflammatory biomarkers and clinicopathological parameters.American journal of cancer research · 2025Article
- Development and Validation of Machine Learning Model Platelet Index-based Predictor for Colorectal Cancer Stage.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Characteristics and risk factor analyses of high-grade intraepithelial neoplasia in older patients with colorectal polyps.World journal of gastrointestinal oncology · 2024Article
- A Systematic Review and Meta-Analysis of Mean Platelet Volume and Platelet Distribution Width in Patients with Obstructive Sleep Apnoea Syndrome.Biomedicines · 2024Review
- Clinical Value of Mean Platelet Volume to Platelet Ratio (MPR) in Distinguishing Mass-Forming Chronic Pancreatitis and Pancreatic Cancer.Diagnostics (Basel, Switzerland) · 2023Article
- Emerging Role of Tumor-Educated Platelets as a New Liquid Biopsy Tool for Colorectal Cancer.Archives of Iranian medicine · 2023Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMean platelet volume (MPV) is a marker of platelet activation, which is usually negatively correlated with platelet count (PC). The ratio of MPV to PC (MPV/PC) has an essential role in the diagnosis of multiple malignancies. However, only a few studies investigated the value of MPV/PC in colorectal cancer (CRC) and the combination of MPV/PC with tumor markers in CRC. This retrospective clinical study aimed to evaluate the diagnostic value of MPV/PC and tumor markers (CA72-4, CA125, CA199) used alone or in combination in CRC.
methods200 patients with CRC and 317 patients with colorectal benign polypus pathologically diagnosed during 2019/01/04 to 2022/06/30 were included. Hematological and pathological parameters of the above patients were collected, data were analyzed with Student's t-test, one-way ANOVA or Kruskal-Wallis H test and receiver operating characteristic (ROC) curve, and ROC curve was used to evaluate the diagnostic value of tumor markers and MPV/PC used alone or in combination in CRC.
resultsThe MPV/PC in CRC group was significantly lower than the control group (P < 0.0001). Among the three tumor markers, higher CA125 was correlated with distant metastasis and lower differentiation (P < 0.05), increased CA72-4 indicated positive nerve invasion (P = 0.0174), and elevated CA199 was associated with lymphatic metastasis and positive vascular invasion (P < 0.05). For subgroups regarding tumor anatomical location, both CA125 and CA199 were higher in colon cancer group than rectum cancer group (P = 0.0322, P = 0.0094). MPV/PC was associated with tumor infiltration, regional lymph node metastasis, differentiation and nerve invasion (P < 0.05) and the combination of MPV/PC with the three tumor markers produced a larger AUC with higher sensitivity, specificity and Yuden index than MPV/PC or the three tumor markers used alone to distinguish between CRC and colorectal polyps.
conclusionPreoperative MPV/PC in peripheral blood of patients with CRC was lower than the control group. Meanwhile, the combined detection of tumor markers with MPV/PC can improve the diagnostic value of CRC, revealing the potential of MPV/PC as a promising screening tool in CRC early diagnosis.
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