Evidence map›Paper›PMID 36750739›Full record

ArticlePediatric research2023

Tobacco smoke exposure, the lower airways microbiome and outcomes of ventilated children.

Matthew K Leroue, Kayla M Williamson, Paul C Curtin, Marci K Sontag, Brandie D Wagner, Lilliam Ambroggio, Moira Bixby, Stefanie A Busgang, Sharon E Murphy, Lisa A Peterson and 16 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Microbial influencers: the airway microbiome's role in asthma.The Journal of clinical investigation · 2025
    Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 10 institutions in 1 country.

Matthew K LerouePediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA. matthew.leroue@childrenscolorado.org.
Kayla M WilliamsonBiostatistics and Informatics, University of Colorado, Colorado School of Public Health, Aurora, CO, USA.
Paul C CurtinCHEAR Data Center, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marci K SontagEpidemiology, University of Colorado, Colorado School of Public Health, Aurora, CO, USA.
Brandie D WagnerBiostatistics and Informatics, University of Colorado, Colorado School of Public Health, Aurora, CO, USA.
Lilliam AmbroggioPediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Moira BixbyCHEAR Data Center, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stefanie A BusgangCHEAR Data Center, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sharon E MurphyMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Lisa A PetersonMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Karin R VevangMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Christopher J SipeMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
J Kirk HarrisPediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Ron W ReederPediatrics, University of Utah, Salt Lake City, UT, USA.
Christopher LocandroPediatrics, University of Utah, Salt Lake City, UT, USA.
Todd C CarpenterPediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Aline B MadduxPediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Eric A F SimõesPediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Christina M OsbornePediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Charles E RobertsonMedicine, Division of Infectious Diseases, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Charles LangelierMedicine, Division of Infectious Diseases, University of California San Francisco, San Francisco, CA, USA.
Joseph A CarcilloPediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Kathleen L MeertPediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit, MI, USA.
Murray M PollackPediatrics, Children's National Hospital, Washington, DC, USA.
Patrick S McQuillenPediatrics, University of California San Francisco, San Francisco, CA, USA.
Peter M MouraniPediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Children's Hospital Colorado · USUniversity of Minnesota Medical Center · USColorado School of Public Health · USIcahn School of Medicine at Mount Sinai · USUniversity of Colorado Denver · USUniversity of California, San Francisco · USUniversity of Utah · USCentral Michigan University · USChildren's National · USUniversity of Pittsburgh · US

Funding

Statistical Services and Methods Development ResourceU2CES026555 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TEITELBAUM, SUSAN L · 2015 to 2025
$26.4M
CPCCRN PRECISE SupplementPL1HD105462 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jonathan Michael Dean · 2021 to 2026
$17.5M
Untargeted Analysis ResourceU2CES026533 · NIEHS · UNIVERSITY OF MINNESOTA · PI PETERSON, LISA A · 2015 to 2025
$14.0M
Untargeted Analysis ResourceU2CES026553 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MEEKER, JOHN D. · 2015 to 2015
$9.5M
National Exposure Assessment Laboratory at EmoryU2CES026560 · NIEHS · EMORY UNIVERSITY · PI WALLER, LANCE A · 2015 to 2015
$8.3M
The Microbiome, Virome and Host Responses Preceding Ventilator-Associated PneumonR01HL124103 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MOURANI, PETER M, SONTAG, MARCI K · 2014 to 2017
$2.7M
Collaborative Network Study of Airway Microbiome and Host Responses in Pediatric Respiratory FailureUG1HD083171 · NICHD · UNIVERSITY OF COLORADO DENVER · PI CARPENTER, TODD C · 2015 to 2020
$1.5M
Profiling the Lung Transcriptome for Precision Diagnosis of Respiratory Infections using Host/Pathogen Metagenomic SequencingK23HL138461 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANGELIER, CHARLES · 2018 to 2021
$718k
NHLBI NIH HHS K23 HL138461NHLBI NIH HHS R01 HL124103NICHD NIH HHS PL1 HD105462NICHD NIH HHS UG1 HD083171NIEHS NIH HHS U2C ES026533NIEHS NIH HHS U2C ES026553NIEHS NIH HHS U2C ES026555NIEHS NIH HHS U2C ES026560
6 · The paper itself

Abstract

backgroundTobacco smoke exposure increases the risk and severity of lower respiratory tract infections in children, yet the mechanisms remain unclear. We hypothesized that tobacco smoke exposure would modify the lower airway microbiome.

methodsSecondary analysis of a multicenter cohort of 362 children between ages 31 days and 18 years mechanically ventilated for >72 h. Tracheal aspirates from 298 patients, collected within 24 h of intubation, were evaluated via 16 S ribosomal RNA sequencing. Smoke exposure was determined by creatinine corrected urine cotinine levels ≥30 µg/g.

resultsPatients had a median age of 16 (IQR 568) months. The most common admission diagnosis was lower respiratory tract infection (53%). Seventy-four (20%) patients were smoke exposed and exhibited decreased richness and Shannon diversity. Smoke exposed children had higher relative abundances of Serratia spp., Moraxella spp., Haemophilus spp., and Staphylococcus aureus. Differences were most notable in patients with bacterial and viral respiratory infections. There were no differences in development of acute respiratory distress syndrome, days of mechanical ventilation, ventilator free days at 28 days, length of stay, or mortality.

conclusionAmong critically ill children requiring prolonged mechanical ventilation, tobacco smoke exposure is associated with decreased richness and Shannon diversity and change in microbial communities. IMPACT: Tobacco smoke exposure is associated with changes in the lower airways microbiome but is not associated with clinical outcomes among critically ill pediatric patients requiring prolonged mechanical ventilation. This study is among the first to evaluate the impact of tobacco smoke exposure on the lower airway microbiome in children. This research helps elucidate the relationship between tobacco smoke exposure and the lower airway microbiome and may provide a possible mechanism by which tobacco smoke exposure increases the risk for poor outcomes in children.

Indexed as

MicrobiotaRespiratory Tract InfectionsTobacco Smoke PollutionChildCotinineCritical IllnessHumansRespiration, ArtificialSmokeCotinineSmokeTobacco Smoke Pollution

Identifiers

PMID36750739
PMCPMC9903281
OpenAlexW4319349232

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.