Evidence map›Paper›PMID 36750538›Full record

ArticleMolecular diversity2024

Design and synthesis of some novel hybrid molecules based on 4-thiazolidinone bearing pyridine-pyrazole scaffolds: molecular docking and molecular dynamics simulations of its major constituent onto DNA gyrase inhibition.

Nisheeth C Desai, Dharmpalsinh J Jadeja, Aratiba M Jethawa, Iqrar Ahmad, Harun Patel, B P Dave

Abstract read
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Article in Molecular diversity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nisheeth C DesaiDivision of Medicinal Chemistry, Department of Chemistry, Maharaja Krishnakumarsinhji Bhavnagar University, Mahatma Gandhi Campus, Bhavnagar, 364 002, India. dnisheeth@rediffmail.com.ORCID http://orcid.org/0000-0001-6864-8661
Dharmpalsinh J JadejaDivision of Medicinal Chemistry, Department of Chemistry, Maharaja Krishnakumarsinhji Bhavnagar University, Mahatma Gandhi Campus, Bhavnagar, 364 002, India.
Aratiba M JethawaDivision of Medicinal Chemistry, Department of Chemistry, Maharaja Krishnakumarsinhji Bhavnagar University, Mahatma Gandhi Campus, Bhavnagar, 364 002, India.
Iqrar AhmadDivision of Computer Aided Drug Design, Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, 425405, India.
Harun PatelDivision of Computer Aided Drug Design, Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, 425405, India.
B P DaveSchool of Science, Indrashil University, Rajpur, Kadi, Gujarat, 382740, India.
Bhavnagar University · INShri Vile Parle Kelavani Mandal · INIndrashil University · IN

Funding

UGC-DAE Consortium for Scientific Research, University Grants Commission No. F18-1/2011 [BSR])
6 · The paper itself

Abstract

Due to multidrug resistance, microbial infections have become significant on a global level. As infections caused by several resistant bacteria and fungi severely harm mankind, scientists have developed new antibiotics to combat these infections. In order to develop novel antimicrobial agents, a series of 4-thiazolidinone-based 5-arylidene hybrids (5a-o) have been designed and synthesized to evaluate their antibacterial and antifungal activities. For the determination of the structure of a novel synthesized hybrid, various spectral techniques, e.g., IR,

Indexed as

DNA GyrasePyrazolesPyridinesThiazolidinesTopoisomerase II InhibitorsAnti-Bacterial AgentsAntifungal AgentsBacteriaCandida albicansDrug DesignMicrobial Sensitivity TestsMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity Relationship4-thiazolidinoneAnti-Bacterial AgentsAntifungal AgentsDNA GyrasepyrazolePyrazolespyridinePyridinesThiazolidinesTopoisomerase II Inhibitors4-ThiazolidinoneAntibacterialAntifungalPyrazolePyridine

Identifiers

PMID36750538
OpenAlexW4319461533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.