ArticleNeurology2023
Patient Relevance of the Modified Rankin Scale in Subarachnoid Hemorrhage Research: An International Cross-sectional Survey.
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Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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11citing papers in PubMed, 1 pooled it
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between systemic immune-inflammation index and the short-term functional outcome of patients with aneurysmal subarachnoid hemorrhage: a meta-analysis.Neurosurgical review · 2025Pooled it
- Evaluating Utility-Weighted Modified Rankin Scale as an Outcome for Clinical Trials in Subarachnoid Hemorrhage: A SAHaRA Secondary Analysis.Neurocritical care · 2026Article
- Psychometric properties of the Chinese version of the Subarachnoid Hemorrhage Outcomes Tool (SAHOT) in elderly SAH patients.BMC geriatrics · 2026Article
- Prognostic impact of neurological dysfunction assessed by modified Rankin Scale in acute myocardial infarction.Scientific reports · 2026Article
- Assessment of outcomes in postaneurysmal subarachnoid bleed patients admitted to the intensive care unit utilizing the subarachnoid haemorrhage international trialist clinicoradiological prediction model for dichotomised functional outcome and mortality.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Grading Scores for Identifying Patients at Risk of Delayed Cerebral Ischemia and Neurological Outcome in Spontaneous Subarachnoid Hemorrhage: A Comparison of Receiver Operator Curve Analysis.Neurocritical care · 2025Article
- Leveraging Ensemble Models and Follow-up Data for Accurate Prediction of mRS Scores from Radiomic Features of DSC-PWI Images.Journal of imaging informatics in medicine · 2025Article
- Timing of neuroprognostication in the ICU.Current opinion in critical care · 2025Review
- Multidimensional outcome after endovascular or microsurgical occlusion of ruptured intracranial aneurysms - Comparative analysis of a prospective Swiss multicenter study.Brain & spine · 2025Article
- Advancing a Patient- and Carer-Centered Approach for the Clinical Development of New Therapeutics for Aneurysmal Subarachnoid Hemorrhage: Insights From a Qualitative Study.Journal of patient-centered research and reviews · 2025Article
- Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist.Intensive care medicine · 2024Review
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Authors and funding
17 authors.
Naomi NiznickFrom the Department of Medicine (Neurology) (N.N.), Ottawa Hospital Research Institute (V.S., J.P., L.M., D.F., T.R., S.E.), Patient Partner (M.L.M., J.L., X.Z.), Ottawa Hospital Research Institute, and Department of Medicine (Critical Care) (L.M., S.E.), The Ottawa Hospital, ON, Canada; The George Institute for Global Health (C.A.), Sydney, NSW, Australia; School of Epidemiology and Public Health (J.P., T.R.), University of Ottawa, ON; Department of Medicine (M.C.), Université de Montréal, Montréal, QC; CHUM Research Center (M.C.), Montréal, QC; Population Health and Optimal Health Practices Research Unit (A.F.T., F.L.), CHU de Québec-Université Laval Research Center, QC; Departments of Anesthesiology & Critical Care (A.F.T., F.L.), and Medicine (F.L.), Université Laval, QC, Canada; Departments of Neurology and Neurosurgery (S.A.M.), Westchester Health Network, New York Medical College, Valhalla; and Departments of Neurology, Neurosurgery, and Biomedical Sciences (S.L.), Cedars-Sinai Medical Center, Los Angeles, CA. naniznick@toh.ca.ORCID 0000-0003-0935-9135
Victoria SaigleFrom the Department of Medicine (Neurology) (N.N.), Ottawa Hospital Research Institute (V.S., J.P., L.M., D.F., T.R., S.E.), Patient Partner (M.L.M., J.L., X.Z.), Ottawa Hospital Research Institute, and Department of Medicine (Critical Care) (L.M., S.E.), The Ottawa Hospital, ON, Canada; The George Institute for Global Health (C.A.), Sydney, NSW, Australia; School of Epidemiology and Public Health (J.P., T.R.), University of Ottawa, ON; Department of Medicine (M.C.), Université de Montréal, Montréal, QC; CHUM Research Center (M.C.), Montréal, QC; Population Health and Optimal Health Practices Research Unit (A.F.T., F.L.), CHU de Québec-Université Laval Research Center, QC; Departments of Anesthesiology & Critical Care (A.F.T., F.L.), and Medicine (F.L.), Université Laval, QC, Canada; Departments of Neurology and Neurosurgery (S.A.M.), Westchester Health Network, New York Medical College, Valhalla; and Departments of Neurology, Neurosurgery, and Biomedical Sciences (S.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
Maria Luisa MartiFrom the Department of Medicine (Neurology) (N.N.), Ottawa Hospital Research Institute (V.S., J.P., L.M., D.F., T.R., S.E.), Patient Partner (M.L.M., J.L., X.Z.), Ottawa Hospital Research Institute, and Department of Medicine (Critical Care) (L.M., S.E.), The Ottawa Hospital, ON, Canada; The George Institute for Global Health (C.A.), Sydney, NSW, Australia; School of Epidemiology and Public Health (J.P., T.R.), University of Ottawa, ON; Department of Medicine (M.C.), Université de Montréal, Montréal, QC; CHUM Research Center (M.C.), Montréal, QC; Population Health and Optimal Health Practices Research Unit (A.F.T., F.L.), CHU de Québec-Université Laval Research Center, QC; Departments of Anesthesiology & Critical Care (A.F.T., F.L.), and Medicine (F.L.), Université Laval, QC, Canada; Departments of Neurology and Neurosurgery (S.A.M.), Westchester Health Network, New York Medical College, Valhalla; and Departments of Neurology, Neurosurgery, and Biomedical Sciences (S.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
Josephine LaframboiseFrom the Department of Medicine (Neurology) (N.N.), Ottawa Hospital Research Institute (V.S., J.P., L.M., D.F., T.R., S.E.), Patient Partner (M.L.M., J.L., X.Z.), Ottawa Hospital Research Institute, and Department of Medicine (Critical Care) (L.M., S.E.), The Ottawa Hospital, ON, Canada; The George Institute for Global Health (C.A.), Sydney, NSW, Australia; School of Epidemiology and Public Health (J.P., T.R.), University of Ottawa, ON; Department of Medicine (M.C.), Université de Montréal, Montréal, QC; CHUM Research Center (M.C.), Montréal, QC; Population Health and Optimal Health Practices Research Unit (A.F.T., F.L.), CHU de Québec-Université Laval Research Center, QC; Departments of Anesthesiology & Critical Care (A.F.T., F.L.), and Medicine (F.L.), Université Laval, QC, Canada; Departments of Neurology and Neurosurgery (S.A.M.), Westchester Health Network, New York Medical College, Valhalla; and Departments of Neurology, Neurosurgery, and Biomedical Sciences (S.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
Xiaohui ZhaFrom the Department of Medicine (Neurology) (N.N.), Ottawa Hospital Research Institute (V.S., J.P., L.M., D.F., T.R., S.E.), Patient Partner (M.L.M., J.L., X.Z.), Ottawa Hospital Research Institute, and Department of Medicine (Critical Care) (L.M., S.E.), The Ottawa Hospital, ON, Canada; The George Institute for Global Health (C.A.), Sydney, NSW, Australia; School of Epidemiology and Public Health (J.P., T.R.), University of Ottawa, ON; Department of Medicine (M.C.), Université de Montréal, Montréal, QC; CHUM Research Center (M.C.), Montréal, QC; Population Health and Optimal Health Practices Research Unit (A.F.T., F.L.), CHU de Québec-Université Laval Research Center, QC; Departments of Anesthesiology & Critical Care (A.F.T., F.L.), and Medicine (F.L.), Université Laval, QC, Canada; Departments of Neurology and Neurosurgery (S.A.M.), Westchester Health Network, New York Medical College, Valhalla; and Departments of Neurology, Neurosurgery, and Biomedical Sciences (S.L.), Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0003-2873-3073
Chris AndersenFrom the Department of Medicine (Neurology) (N.N.), Ottawa Hospital Research Institute (V.S., J.P., L.M., D.F., T.R., S.E.), Patient Partner (M.L.M., J.L., X.Z.), Ottawa Hospital Research Institute, and Department of Medicine (Critical Care) (L.M., S.E.), The Ottawa Hospital, ON, Canada; The George Institute for Global Health (C.A.), Sydney, NSW, Australia; School of Epidemiology and Public Health (J.P., T.R.), University of Ottawa, ON; Department of Medicine (M.C.), Université de Montréal, Montréal, QC; CHUM Research Center (M.C.), Montréal, QC; Population Health and Optimal Health Practices Research Unit (A.F.T., F.L.), CHU de Québec-Université Laval Research Center, QC; Departments of Anesthesiology & Critical Care (A.F.T., F.L.), and Medicine (F.L.), Université Laval, QC, Canada; Departments of Neurology and Neurosurgery (S.A.M.), Westchester Health Network, New York Medical College, Valhalla; and Departments of Neurology, Neurosurgery, and Biomedical Sciences (S.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
Justin PresseauFrom the Department of Medicine (Neurology) (N.N.), Ottawa Hospital Research Institute (V.S., J.P., L.M., D.F., T.R., S.E.), Patient Partner (M.L.M., J.L., X.Z.), Ottawa Hospital Research Institute, and Department of Medicine (Critical Care) (L.M., S.E.), The Ottawa Hospital, ON, Canada; The George Institute for Global Health (C.A.), Sydney, NSW, Australia; School of Epidemiology and Public Health (J.P., T.R.), University of Ottawa, ON; Department of Medicine (M.C.), Université de Montréal, Montréal, QC; CHUM Research Center (M.C.), Montréal, QC; Population Health and Optimal Health Practices Research Unit (A.F.T., F.L.), CHU de Québec-Université Laval Research Center, QC; Departments of Anesthesiology & Critical Care (A.F.T., F.L.), and Medicine (F.L.), Université Laval, QC, Canada; Departments of Neurology and Neurosurgery (S.A.M.), Westchester Health Network, New York Medical College, Valhalla; and Departments of Neurology, Neurosurgery, and Biomedical Sciences (S.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
Michaël ChasséFrom the Department of Medicine (Neurology) (N.N.), Ottawa Hospital Research Institute (V.S., J.P., L.M., D.F., T.R., S.E.), Patient Partner (M.L.M., J.L., X.Z.), Ottawa Hospital Research Institute, and Department of Medicine (Critical Care) (L.M., S.E.), The Ottawa Hospital, ON, Canada; The George Institute for Global Health (C.A.), Sydney, NSW, Australia; School of Epidemiology and Public Health (J.P., T.R.), University of Ottawa, ON; Department of Medicine (M.C.), Université de Montréal, Montréal, QC; CHUM Research Center (M.C.), Montréal, QC; Population Health and Optimal Health Practices Research Unit (A.F.T., F.L.), CHU de Québec-Université Laval Research Center, QC; Departments of Anesthesiology & Critical Care (A.F.T., F.L.), and Medicine (F.L.), Université Laval, QC, Canada; Departments of Neurology and Neurosurgery (S.A.M.), Westchester Health Network, New York Medical College, Valhalla; and Departments of Neurology, Neurosurgery, and Biomedical Sciences (S.L.), Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0001-7075-1924
Lauralyn McIntyreFrom the Department of Medicine (Neurology) (N.N.), Ottawa Hospital Research Institute (V.S., J.P., L.M., D.F., T.R., S.E.), Patient Partner (M.L.M., J.L., X.Z.), Ottawa Hospital Research Institute, and Department of Medicine (Critical Care) (L.M., S.E.), The Ottawa Hospital, ON, Canada; The George Institute for Global Health (C.A.), Sydney, NSW, Australia; School of Epidemiology and Public Health (J.P., T.R.), University of Ottawa, ON; Department of Medicine (M.C.), Université de Montréal, Montréal, QC; CHUM Research Center (M.C.), Montréal, QC; Population Health and Optimal Health Practices Research Unit (A.F.T., F.L.), CHU de Québec-Université Laval Research Center, QC; Departments of Anesthesiology & Critical Care (A.F.T., F.L.), and Medicine (F.L.), Université Laval, QC, Canada; Departments of Neurology and Neurosurgery (S.A.M.), Westchester Health Network, New York Medical College, Valhalla; and Departments of Neurology, Neurosurgery, and Biomedical Sciences (S.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
Dean FergussonFrom the Department of Medicine (Neurology) (N.N.), Ottawa Hospital Research Institute (V.S., J.P., L.M., D.F., T.R., S.E.), Patient Partner (M.L.M., J.L., X.Z.), Ottawa Hospital Research Institute, and Department of Medicine (Critical Care) (L.M., S.E.), The Ottawa Hospital, ON, Canada; The George Institute for Global Health (C.A.), Sydney, NSW, Australia; School of Epidemiology and Public Health (J.P., T.R.), University of Ottawa, ON; Department of Medicine (M.C.), Université de Montréal, Montréal, QC; CHUM Research Center (M.C.), Montréal, QC; Population Health and Optimal Health Practices Research Unit (A.F.T., F.L.), CHU de Québec-Université Laval Research Center, QC; Departments of Anesthesiology & Critical Care (A.F.T., F.L.), and Medicine (F.L.), Université Laval, QC, Canada; Departments of Neurology and Neurosurgery (S.A.M.), Westchester Health Network, New York Medical College, Valhalla; and Departments of Neurology, Neurosurgery, and Biomedical Sciences (S.L.), Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0002-3389-2485
Alexis F TurgeonFrom the Department of Medicine (Neurology) (N.N.), Ottawa Hospital Research Institute (V.S., J.P., L.M., D.F., T.R., S.E.), Patient Partner (M.L.M., J.L., X.Z.), Ottawa Hospital Research Institute, and Department of Medicine (Critical Care) (L.M., S.E.), The Ottawa Hospital, ON, Canada; The George Institute for Global Health (C.A.), Sydney, NSW, Australia; School of Epidemiology and Public Health (J.P., T.R.), University of Ottawa, ON; Department of Medicine (M.C.), Université de Montréal, Montréal, QC; CHUM Research Center (M.C.), Montréal, QC; Population Health and Optimal Health Practices Research Unit (A.F.T., F.L.), CHU de Québec-Université Laval Research Center, QC; Departments of Anesthesiology & Critical Care (A.F.T., F.L.), and Medicine (F.L.), Université Laval, QC, Canada; Departments of Neurology and Neurosurgery (S.A.M.), Westchester Health Network, New York Medical College, Valhalla; and Departments of Neurology, Neurosurgery, and Biomedical Sciences (S.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
François LauzierFrom the Department of Medicine (Neurology) (N.N.), Ottawa Hospital Research Institute (V.S., J.P., L.M., D.F., T.R., S.E.), Patient Partner (M.L.M., J.L., X.Z.), Ottawa Hospital Research Institute, and Department of Medicine (Critical Care) (L.M., S.E.), The Ottawa Hospital, ON, Canada; The George Institute for Global Health (C.A.), Sydney, NSW, Australia; School of Epidemiology and Public Health (J.P., T.R.), University of Ottawa, ON; Department of Medicine (M.C.), Université de Montréal, Montréal, QC; CHUM Research Center (M.C.), Montréal, QC; Population Health and Optimal Health Practices Research Unit (A.F.T., F.L.), CHU de Québec-Université Laval Research Center, QC; Departments of Anesthesiology & Critical Care (A.F.T., F.L.), and Medicine (F.L.), Université Laval, QC, Canada; Departments of Neurology and Neurosurgery (S.A.M.), Westchester Health Network, New York Medical College, Valhalla; and Departments of Neurology, Neurosurgery, and Biomedical Sciences (S.L.), Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0002-6530-5513
Stephan A MayerFrom the Department of Medicine (Neurology) (N.N.), Ottawa Hospital Research Institute (V.S., J.P., L.M., D.F., T.R., S.E.), Patient Partner (M.L.M., J.L., X.Z.), Ottawa Hospital Research Institute, and Department of Medicine (Critical Care) (L.M., S.E.), The Ottawa Hospital, ON, Canada; The George Institute for Global Health (C.A.), Sydney, NSW, Australia; School of Epidemiology and Public Health (J.P., T.R.), University of Ottawa, ON; Department of Medicine (M.C.), Université de Montréal, Montréal, QC; CHUM Research Center (M.C.), Montréal, QC; Population Health and Optimal Health Practices Research Unit (A.F.T., F.L.), CHU de Québec-Université Laval Research Center, QC; Departments of Anesthesiology & Critical Care (A.F.T., F.L.), and Medicine (F.L.), Université Laval, QC, Canada; Departments of Neurology and Neurosurgery (S.A.M.), Westchester Health Network, New York Medical College, Valhalla; and Departments of Neurology, Neurosurgery, and Biomedical Sciences (S.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
Shouri LahiriFrom the Department of Medicine (Neurology) (N.N.), Ottawa Hospital Research Institute (V.S., J.P., L.M., D.F., T.R., S.E.), Patient Partner (M.L.M., J.L., X.Z.), Ottawa Hospital Research Institute, and Department of Medicine (Critical Care) (L.M., S.E.), The Ottawa Hospital, ON, Canada; The George Institute for Global Health (C.A.), Sydney, NSW, Australia; School of Epidemiology and Public Health (J.P., T.R.), University of Ottawa, ON; Department of Medicine (M.C.), Université de Montréal, Montréal, QC; CHUM Research Center (M.C.), Montréal, QC; Population Health and Optimal Health Practices Research Unit (A.F.T., F.L.), CHU de Québec-Université Laval Research Center, QC; Departments of Anesthesiology & Critical Care (A.F.T., F.L.), and Medicine (F.L.), Université Laval, QC, Canada; Departments of Neurology and Neurosurgery (S.A.M.), Westchester Health Network, New York Medical College, Valhalla; and Departments of Neurology, Neurosurgery, and Biomedical Sciences (S.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
Tim RamsayFrom the Department of Medicine (Neurology) (N.N.), Ottawa Hospital Research Institute (V.S., J.P., L.M., D.F., T.R., S.E.), Patient Partner (M.L.M., J.L., X.Z.), Ottawa Hospital Research Institute, and Department of Medicine (Critical Care) (L.M., S.E.), The Ottawa Hospital, ON, Canada; The George Institute for Global Health (C.A.), Sydney, NSW, Australia; School of Epidemiology and Public Health (J.P., T.R.), University of Ottawa, ON; Department of Medicine (M.C.), Université de Montréal, Montréal, QC; CHUM Research Center (M.C.), Montréal, QC; Population Health and Optimal Health Practices Research Unit (A.F.T., F.L.), CHU de Québec-Université Laval Research Center, QC; Departments of Anesthesiology & Critical Care (A.F.T., F.L.), and Medicine (F.L.), Université Laval, QC, Canada; Departments of Neurology and Neurosurgery (S.A.M.), Westchester Health Network, New York Medical College, Valhalla; and Departments of Neurology, Neurosurgery, and Biomedical Sciences (S.L.), Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0001-8478-8170
Shane EnglishFrom the Department of Medicine (Neurology) (N.N.), Ottawa Hospital Research Institute (V.S., J.P., L.M., D.F., T.R., S.E.), Patient Partner (M.L.M., J.L., X.Z.), Ottawa Hospital Research Institute, and Department of Medicine (Critical Care) (L.M., S.E.), The Ottawa Hospital, ON, Canada; The George Institute for Global Health (C.A.), Sydney, NSW, Australia; School of Epidemiology and Public Health (J.P., T.R.), University of Ottawa, ON; Department of Medicine (M.C.), Université de Montréal, Montréal, QC; CHUM Research Center (M.C.), Montréal, QC; Population Health and Optimal Health Practices Research Unit (A.F.T., F.L.), CHU de Québec-Université Laval Research Center, QC; Departments of Anesthesiology & Critical Care (A.F.T., F.L.), and Medicine (F.L.), Université Laval, QC, Canada; Departments of Neurology and Neurosurgery (S.A.M.), Westchester Health Network, New York Medical College, Valhalla; and Departments of Neurology, Neurosurgery, and Biomedical Sciences (S.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
APOC Investigators and the Canadian Critical Care Trials Group
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThere is significant heterogeneity in the reporting of outcome measures in aneurysmal subarachnoid hemorrhage (aSAH) research. The modified Rankin scale (mRS) is the most commonly reported functional outcome measure. The mRS focuses on physical disability; however, many aSAH survivors experience sequalae in other domains, and the mRS may therefore not capture outcomes important to aSAH survivors. The objective of this study was to assess the clinical relevance of the mRS as a research outcome measure to people with lived aSAH experience.
methodsWe conducted an international cross-sectional survey of 355 aSAH survivors, family members, and caregivers to evaluate patient-perceived outcomes in relation to the mRS. The mRS was assessed using a previously validated web-based tool.
resultsResponse rate was 60%; respondents from 7 continents were composed of 86% aSAH survivors and 14% family members/caregivers. Agreement between self-assessed outcome and the mRS was poor (Kappa 0.26 [CI 0.14-0.39]). Of the 172 respondents who self-assessed as having had a good aSAH outcome, 122 (71%) had a score of 0-2 on the mRS. Approximately 19% of respondents with a good outcome, based on a measured mRS score of 0-2, self-assessed as having had a poor aSAH outcome. When the mRS score was dichotomized as 0-3 corresponding to a good outcome, agreement between the score and self-assessed outcome remained poor with a Kappa score of 0.40 (CI 0.20-0.60). Approximately 30% of respondents believed that the mRS should not be used as an outcome measure in future aSAH trials. DISCUSSION: The findings suggest that there is poor agreement between aSAH survivors' self-assessed outcome, their actual mRS score, and the dichotomization of the mRS score into good/poor outcomes. Patient-centered and patient-informed outcome measurement tools are needed to guide the aSAH research agenda.
Indexed as
Subarachnoid HemorrhageCross-Sectional StudiesHumansOutcome Assessment, Health CarePatientsRetrospective Studies
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