Evidence map›Paper›PMID 36750386›Full record

ArticleNeurology2023

Contribution of White Matter Fiber Bundle Damage to Language Change After Surgery for Temporal Lobe Epilepsy.

Lawrence Peter Binding, Debayan Dasgupta, Peter Neal Taylor, Pamela Jane Thompson, Aidan G O'Keeffe, Jane de Tisi, Andrew William McEvoy, Anna Miserocchi, Gavin P Winston, John S Duncan and 1 more

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In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Clinical and anatomical characteristics of basal temporal seizures: A systematic review.Epileptic disorders : international epilepsy journal with videotape · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lawrence Peter BindingFrom the Department of Computer Science (L.P.B., S.B.V.), Centre for Medical Image Computing, Department of Clinical and Experimental Epilepsy (L.B.P., D.D., P.N.T., P.J.T., J.d.T., A.W.M., A.M., G.P.W., J.S.D.), UCL Queen Square Institute of Neurology, and Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, University College London; Victor Horsley Department of Neurosurgery (D.D., A.W.M., A.M.), and Department of Neuropsychology (P.J.T.), National Hospital for Neurology and Neurosurgery, Queen Square, London; CNNP Lab (P.N.T.), Interdisciplinary Computing and Complex BioSystems Group, School of Computing Science, Newcastle University; School of Mathematical Sciences (A.G.O.), University of Nottingham; Epilepsy Society MRI Unit (J.d.T., G.P.W., J.S.D.), Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom; Department of Medicine (G.P.W.), Division of Neurology, Queen's University, Kingston, Canada; and Centre for Microscopy (S.B.V), Characterisation, and Analysis, The University of Western Australia, Nedlands, Australia. lawrence.binding.19@ucl.ac.uk.ORCID 0000-0002-5658-4960
Debayan DasguptaFrom the Department of Computer Science (L.P.B., S.B.V.), Centre for Medical Image Computing, Department of Clinical and Experimental Epilepsy (L.B.P., D.D., P.N.T., P.J.T., J.d.T., A.W.M., A.M., G.P.W., J.S.D.), UCL Queen Square Institute of Neurology, and Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, University College London; Victor Horsley Department of Neurosurgery (D.D., A.W.M., A.M.), and Department of Neuropsychology (P.J.T.), National Hospital for Neurology and Neurosurgery, Queen Square, London; CNNP Lab (P.N.T.), Interdisciplinary Computing and Complex BioSystems Group, School of Computing Science, Newcastle University; School of Mathematical Sciences (A.G.O.), University of Nottingham; Epilepsy Society MRI Unit (J.d.T., G.P.W., J.S.D.), Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom; Department of Medicine (G.P.W.), Division of Neurology, Queen's University, Kingston, Canada; and Centre for Microscopy (S.B.V), Characterisation, and Analysis, The University of Western Australia, Nedlands, Australia.ORCID 0000-0002-1064-0541
Peter Neal TaylorFrom the Department of Computer Science (L.P.B., S.B.V.), Centre for Medical Image Computing, Department of Clinical and Experimental Epilepsy (L.B.P., D.D., P.N.T., P.J.T., J.d.T., A.W.M., A.M., G.P.W., J.S.D.), UCL Queen Square Institute of Neurology, and Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, University College London; Victor Horsley Department of Neurosurgery (D.D., A.W.M., A.M.), and Department of Neuropsychology (P.J.T.), National Hospital for Neurology and Neurosurgery, Queen Square, London; CNNP Lab (P.N.T.), Interdisciplinary Computing and Complex BioSystems Group, School of Computing Science, Newcastle University; School of Mathematical Sciences (A.G.O.), University of Nottingham; Epilepsy Society MRI Unit (J.d.T., G.P.W., J.S.D.), Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom; Department of Medicine (G.P.W.), Division of Neurology, Queen's University, Kingston, Canada; and Centre for Microscopy (S.B.V), Characterisation, and Analysis, The University of Western Australia, Nedlands, Australia.ORCID 0000-0003-2144-9838
Pamela Jane ThompsonFrom the Department of Computer Science (L.P.B., S.B.V.), Centre for Medical Image Computing, Department of Clinical and Experimental Epilepsy (L.B.P., D.D., P.N.T., P.J.T., J.d.T., A.W.M., A.M., G.P.W., J.S.D.), UCL Queen Square Institute of Neurology, and Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, University College London; Victor Horsley Department of Neurosurgery (D.D., A.W.M., A.M.), and Department of Neuropsychology (P.J.T.), National Hospital for Neurology and Neurosurgery, Queen Square, London; CNNP Lab (P.N.T.), Interdisciplinary Computing and Complex BioSystems Group, School of Computing Science, Newcastle University; School of Mathematical Sciences (A.G.O.), University of Nottingham; Epilepsy Society MRI Unit (J.d.T., G.P.W., J.S.D.), Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom; Department of Medicine (G.P.W.), Division of Neurology, Queen's University, Kingston, Canada; and Centre for Microscopy (S.B.V), Characterisation, and Analysis, The University of Western Australia, Nedlands, Australia.
Aidan G O'KeeffeFrom the Department of Computer Science (L.P.B., S.B.V.), Centre for Medical Image Computing, Department of Clinical and Experimental Epilepsy (L.B.P., D.D., P.N.T., P.J.T., J.d.T., A.W.M., A.M., G.P.W., J.S.D.), UCL Queen Square Institute of Neurology, and Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, University College London; Victor Horsley Department of Neurosurgery (D.D., A.W.M., A.M.), and Department of Neuropsychology (P.J.T.), National Hospital for Neurology and Neurosurgery, Queen Square, London; CNNP Lab (P.N.T.), Interdisciplinary Computing and Complex BioSystems Group, School of Computing Science, Newcastle University; School of Mathematical Sciences (A.G.O.), University of Nottingham; Epilepsy Society MRI Unit (J.d.T., G.P.W., J.S.D.), Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom; Department of Medicine (G.P.W.), Division of Neurology, Queen's University, Kingston, Canada; and Centre for Microscopy (S.B.V), Characterisation, and Analysis, The University of Western Australia, Nedlands, Australia.
Jane de TisiFrom the Department of Computer Science (L.P.B., S.B.V.), Centre for Medical Image Computing, Department of Clinical and Experimental Epilepsy (L.B.P., D.D., P.N.T., P.J.T., J.d.T., A.W.M., A.M., G.P.W., J.S.D.), UCL Queen Square Institute of Neurology, and Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, University College London; Victor Horsley Department of Neurosurgery (D.D., A.W.M., A.M.), and Department of Neuropsychology (P.J.T.), National Hospital for Neurology and Neurosurgery, Queen Square, London; CNNP Lab (P.N.T.), Interdisciplinary Computing and Complex BioSystems Group, School of Computing Science, Newcastle University; School of Mathematical Sciences (A.G.O.), University of Nottingham; Epilepsy Society MRI Unit (J.d.T., G.P.W., J.S.D.), Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom; Department of Medicine (G.P.W.), Division of Neurology, Queen's University, Kingston, Canada; and Centre for Microscopy (S.B.V), Characterisation, and Analysis, The University of Western Australia, Nedlands, Australia.
Andrew William McEvoyFrom the Department of Computer Science (L.P.B., S.B.V.), Centre for Medical Image Computing, Department of Clinical and Experimental Epilepsy (L.B.P., D.D., P.N.T., P.J.T., J.d.T., A.W.M., A.M., G.P.W., J.S.D.), UCL Queen Square Institute of Neurology, and Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, University College London; Victor Horsley Department of Neurosurgery (D.D., A.W.M., A.M.), and Department of Neuropsychology (P.J.T.), National Hospital for Neurology and Neurosurgery, Queen Square, London; CNNP Lab (P.N.T.), Interdisciplinary Computing and Complex BioSystems Group, School of Computing Science, Newcastle University; School of Mathematical Sciences (A.G.O.), University of Nottingham; Epilepsy Society MRI Unit (J.d.T., G.P.W., J.S.D.), Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom; Department of Medicine (G.P.W.), Division of Neurology, Queen's University, Kingston, Canada; and Centre for Microscopy (S.B.V), Characterisation, and Analysis, The University of Western Australia, Nedlands, Australia.
Anna MiserocchiFrom the Department of Computer Science (L.P.B., S.B.V.), Centre for Medical Image Computing, Department of Clinical and Experimental Epilepsy (L.B.P., D.D., P.N.T., P.J.T., J.d.T., A.W.M., A.M., G.P.W., J.S.D.), UCL Queen Square Institute of Neurology, and Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, University College London; Victor Horsley Department of Neurosurgery (D.D., A.W.M., A.M.), and Department of Neuropsychology (P.J.T.), National Hospital for Neurology and Neurosurgery, Queen Square, London; CNNP Lab (P.N.T.), Interdisciplinary Computing and Complex BioSystems Group, School of Computing Science, Newcastle University; School of Mathematical Sciences (A.G.O.), University of Nottingham; Epilepsy Society MRI Unit (J.d.T., G.P.W., J.S.D.), Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom; Department of Medicine (G.P.W.), Division of Neurology, Queen's University, Kingston, Canada; and Centre for Microscopy (S.B.V), Characterisation, and Analysis, The University of Western Australia, Nedlands, Australia.
Gavin P WinstonFrom the Department of Computer Science (L.P.B., S.B.V.), Centre for Medical Image Computing, Department of Clinical and Experimental Epilepsy (L.B.P., D.D., P.N.T., P.J.T., J.d.T., A.W.M., A.M., G.P.W., J.S.D.), UCL Queen Square Institute of Neurology, and Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, University College London; Victor Horsley Department of Neurosurgery (D.D., A.W.M., A.M.), and Department of Neuropsychology (P.J.T.), National Hospital for Neurology and Neurosurgery, Queen Square, London; CNNP Lab (P.N.T.), Interdisciplinary Computing and Complex BioSystems Group, School of Computing Science, Newcastle University; School of Mathematical Sciences (A.G.O.), University of Nottingham; Epilepsy Society MRI Unit (J.d.T., G.P.W., J.S.D.), Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom; Department of Medicine (G.P.W.), Division of Neurology, Queen's University, Kingston, Canada; and Centre for Microscopy (S.B.V), Characterisation, and Analysis, The University of Western Australia, Nedlands, Australia.ORCID 0000-0001-9394-1478
John S DuncanFrom the Department of Computer Science (L.P.B., S.B.V.), Centre for Medical Image Computing, Department of Clinical and Experimental Epilepsy (L.B.P., D.D., P.N.T., P.J.T., J.d.T., A.W.M., A.M., G.P.W., J.S.D.), UCL Queen Square Institute of Neurology, and Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, University College London; Victor Horsley Department of Neurosurgery (D.D., A.W.M., A.M.), and Department of Neuropsychology (P.J.T.), National Hospital for Neurology and Neurosurgery, Queen Square, London; CNNP Lab (P.N.T.), Interdisciplinary Computing and Complex BioSystems Group, School of Computing Science, Newcastle University; School of Mathematical Sciences (A.G.O.), University of Nottingham; Epilepsy Society MRI Unit (J.d.T., G.P.W., J.S.D.), Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom; Department of Medicine (G.P.W.), Division of Neurology, Queen's University, Kingston, Canada; and Centre for Microscopy (S.B.V), Characterisation, and Analysis, The University of Western Australia, Nedlands, Australia.ORCID 0000-0001-9395-1478
Sjoerd B VosFrom the Department of Computer Science (L.P.B., S.B.V.), Centre for Medical Image Computing, Department of Clinical and Experimental Epilepsy (L.B.P., D.D., P.N.T., P.J.T., J.d.T., A.W.M., A.M., G.P.W., J.S.D.), UCL Queen Square Institute of Neurology, and Neuroradiological Academic Unit (S.B.V.), UCL Queen Square Institute of Neurology, University College London; Victor Horsley Department of Neurosurgery (D.D., A.W.M., A.M.), and Department of Neuropsychology (P.J.T.), National Hospital for Neurology and Neurosurgery, Queen Square, London; CNNP Lab (P.N.T.), Interdisciplinary Computing and Complex BioSystems Group, School of Computing Science, Newcastle University; School of Mathematical Sciences (A.G.O.), University of Nottingham; Epilepsy Society MRI Unit (J.d.T., G.P.W., J.S.D.), Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom; Department of Medicine (G.P.W.), Division of Neurology, Queen's University, Kingston, Canada; and Centre for Microscopy (S.B.V), Characterisation, and Analysis, The University of Western Australia, Nedlands, Australia.ORCID 0000-0002-8502-4487

Funding

Department of HealthMedical Research Council G0802012Medical Research Council MR/M00841X/1Medical Research Council MR/T04294X/1Wellcome Trust 218380/Z/19/Z
6 · The paper itself

Abstract

BACKGROUND AND

objectivesIn medically refractory temporal lobe epilepsy (TLE), 30%-50% of patients experience substantial language decline after resection in the language-dominant hemisphere. In this study, we investigated the contribution of white matter fiber bundle damage to language change at 3 and 12 months after surgery.

methodsWe studied 127 patients who underwent TLE surgery from 2010 to 2019. Neuropsychological testing included picture naming, semantic fluency, and phonemic verbal fluency, performed preoperatively and 3 and 12 months postoperatively. Outcome was assessed using reliable change index (RCI; clinically significant decline) and change across timepoints (postoperative scores minus preoperative scores). Functional MRI was used to determine language lateralization. The arcuate fasciculus (AF), inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus, middle longitudinal fasciculus (MLF), and uncinate fasciculus were mapped using diffusion MRI probabilistic tractography. Resection masks, drawn comparing coregistered preoperative and postoperative T1 MRI scans, were used as exclusion regions on preoperative tractography to estimate the percentage of preoperative tracts transected in surgery. Chi-squared assessments evaluated the occurrence of RCI-determined language decline. Independent sample

resultsLanguage-dominant and language-nondominant resections were treated separately for picture naming because postoperative outcomes were significantly different between these groups. In language-dominant hemisphere resections, greater surgical damage to the AF and IFOF was related to RCI decline at 3 months. Damage to the inferior frontal subfasciculus of the IFOF was related to change at 3 months. In language-nondominant hemisphere resections, increased MLF resection was associated with RCI decline at 3 months, and damage to the anterior subfasciculus was related to change at 3 months. Language-dominant and language-nondominant resections were treated as 1 cohort for semantic and phonemic fluency because there were no significant differences in postoperative decline between these groups. Postoperative seizure freedom was associated with an absence of significant language decline 12 months after surgery for semantic fluency. DISCUSSION: We demonstrate a relationship between fiber transection and naming decline after temporal lobe resection. Individualized surgical planning to spare white matter fiber bundles could help to preserve language function after surgery.

Indexed as

Epilepsy, Temporal LobeWhite MatterHumansLanguageMagnetic Resonance ImagingNeural Pathways

Identifiers

PMID36750386
PMCPMC10103113

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