Evidence map›Paper›PMID 36750316›Full record

ReviewAnnual review of immunology2023

Immune Mechanisms in Inflammatory Anemia.

Susan P Canny, Susana L Orozco, Natalie K Thulin, Jessica A Hamerman

Open access · hybridAbstract readReview
In one paragraph

Review in Annual review of immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Susan P CannyCenter for Fundamental Immunology, Benaroya Research Institute, Seattle, Washington, USA; email: jhamerman@benaroyaresearch.org, scanny@benaroyaresearch.org, sorozco@benaroyaresearch.org, nthulin@benaroyaresearch.org.
Susana L OrozcoCenter for Fundamental Immunology, Benaroya Research Institute, Seattle, Washington, USA; email: jhamerman@benaroyaresearch.org, scanny@benaroyaresearch.org, sorozco@benaroyaresearch.org, nthulin@benaroyaresearch.org.
Natalie K ThulinCenter for Fundamental Immunology, Benaroya Research Institute, Seattle, Washington, USA; email: jhamerman@benaroyaresearch.org, scanny@benaroyaresearch.org, sorozco@benaroyaresearch.org, nthulin@benaroyaresearch.org.
Jessica A HamermanCenter for Fundamental Immunology, Benaroya Research Institute, Seattle, Washington, USA; email: jhamerman@benaroyaresearch.org, scanny@benaroyaresearch.org, sorozco@benaroyaresearch.org, nthulin@benaroyaresearch.org.
Benaroya Research InstituteUniversity of Washington · US

Funding

ACADEMIC PEDIATRIC INFECTIOUS DISEASET32HD007233 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI KEVIN B URDAHL · 1985 to 2026
$6.7M
RESEARCH TRAINING IN RHEUMATOLOGYT32AR007108 · NIAMS · UNIVERSITY OF WASHINGTON · PI Shaun Jackson, Tomas M Mustelin · 1986 to 2026
$6.6M
BCAP regulation of TLR7/9 signaling in LupusR01AI150178 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI HAMERMAN, JESSICA A · 2020 to 2024
$3.7M
IRF5 and Macrophage Activation Syndrome in systemic Juvenile Idiopathic ArthritisR01AR076242 · NIAMS · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI BARNES, BETSY J, HAMERMAN, JESSICA A · 2019 to 2023
$3.3M
Basic Training at the Intersection of Innate and Adaptive Immunity in DiseaseT32AI106677 · NIAID · UNIVERSITY OF WASHINGTON · PI GALE, MICHAEL, GOVERMAN, JOAN M · 2013 to 2022
$2.1M
IgA-containing immune complexes in plasmacytoid dendritic cell activation in SLER21AI154841 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI HAMERMAN, JESSICA A · 2020 to 2021
$479k
Inflammation-associated anemia and the role of monocyte-derived inflammatory hemophagocytes in a model of blood-stage malariaF32HL154700 · NHLBI · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI OROZCO, SUSANA LUCIA · 2020 to 2022
$206k
Defining signals contributing to inflammatory hemophagocyte differentiation in TLR7 mediated Macrophage Activation SyndromeF31AI172078 · NIAID · UNIVERSITY OF WASHINGTON · PI THULIN, NATALIE K · 2022 to 2024
$133k
Defining the role of IRF5 in inflammatory hemophagocyte differentiationF32HL156516 · NHLBI · UNIVERSITY OF WASHINGTON · PI CANNY, SUSAN PRISCILLA · 2021 to 2021
$72k
NHLBI NIH HHS F32 HL154700NHLBI NIH HHS F32 HL156516NIAID NIH HHS F31 AI172078NIAID NIH HHS R01 AI150178NIAID NIH HHS R21 AI154841NIAID NIH HHS T32 AI106677NIAMS NIH HHS R01 AR076242NIAMS NIH HHS T32 AR007108NICHD NIH HHS T32 HD007233
6 · The paper itself

Abstract

Maintaining the correct number of healthy red blood cells (RBCs) is critical for proper oxygenation of tissues throughout the body. Therefore, RBC homeostasis is a tightly controlled balance between RBC production and RBC clearance, through the processes of erythropoiesis and macrophage hemophagocytosis, respectively. However, during the inflammation associated with infectious, autoimmune, or inflammatory diseases this homeostatic process is often dysregulated, leading to acute or chronic anemia. In each disease setting, multiple mechanisms typically contribute to the development of inflammatory anemia, impinging on both sides of the RBC production and RBC clearance equation. These mechanisms include both direct and indirect effects of inflammatory cytokines and innate sensing. Here, we focus on common innate and adaptive immune mechanisms that contribute to inflammatory anemias using examples from several diseases, including hemophagocytic lymphohistiocytosis/macrophage activation syndrome, severe malarial anemia during

Indexed as

AnemiaMalariaAnimalsErythrocytesErythropoiesisHumansMacrophagesanemiahemophagocytehemophagocytic lymphohistiocytosisinflammationmalariasickle cell anemia

Identifiers

PMID36750316
PMCPMC10367595
OpenAlexW4319335644

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.