SynthesisJournal of psychiatry & neuroscience : JPN
Hippocampal subfield alterations in schizophrenia and major depressive disorder: a systematic review and network meta-analysis of anatomic MRI studies.
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In one paragraph
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29citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
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Who cites it
29 citing papers in PubMed, 36 citations in OpenAlex.
- Modelling post-traumatic stress disorder-major depressive disorder comorbidity in rats: impaired α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor signalling is consistent with synergistic behavioural and cognitive deficits.European journal of psychotraumatology · 2026Article
- GATA3 drives chronic stress-induced depressive-like behaviors by reducing hippocampal CA3 pyramidal neuronal activity in male mice.Acta pharmacologica Sinica · 2026Article
- Regional Brain Volume Variation Across Adulthood: A Cross-Sectional MRI Analysis of Age, Sex, and Hemispheric Asymmetry.Life (Basel, Switzerland) · 2026Article
- The applications of single-cell and spatial transcriptomics in neuroscience and brain disorders.Neuroscience and biobehavioral reviews · 2026Review
- Hippocampal Total, Subregion, and Subfield Volume Alterations in Late-Life Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Altered hippocampal shape morphology in schizophrenia and at-risk mental state.Psychiatry research. Neuroimaging · 2026Article
- Hippocampal subfield-specific imaging in depression: the translational power of ultra-high field MRI.Translational psychiatry · 2026Review
- Associations among stress perception, clinical symptoms, and hippocampal subfield volumes in first-episode patients with schizophrenia.Frontiers in psychiatry · 2026Article
- Microglial Sestrin2 alleviates depressive-like behaviors and cognitive impairment in a YTHDF1-dependent manner.Frontiers in neuroscience · 2026Article
- 7T multimodal MRI reveals structural-functional-quantitative susceptibility mapping abnormalities of new daily persistent headache.The journal of headache and pain · 2025Article
- Harmonized Protocol for Segmentation of the Hippocampal Tail on High-ResolutionbioRxiv : the preprint server for biology · 2025Article
- Loneliness in schizophrenia: Just loneliness.Annals of the New York Academy of Sciences · 2025Review
- Neural and somatic mechanisms driving clinical improvements in post-acute schizophrenia spectrum disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Brain structural and functional aberrant of hippocampal subregions was associated with somatic depression.BMC psychiatry · 2025Article
- Review
- Association of concussion history with psychiatric symptoms, limbic system structure, and kynurenine pathway metabolites in healthy, collegiate-aged athletes.Brain, behavior, and immunity · 2025Article
- Exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug-induced Parkinsonism.Frontiers in aging neuroscience · 2025Article
- Hippocampal subfield and amygdala volumes are associated with difficulties in emotion regulation of depressed patients with a history of childhood maltreatment.Frontiers in psychiatry · 2025Article
- The association between childhood adversity and hippocampal volumes is moderated by romantic relationship experiences.The European journal of neuroscience · 2025Article
- Changes in hippocampal volume and affective functioning after a moderate intensity running intervention.Brain structure & function · 2024Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Yuan Sun *From the Huaxi MR Research Center, Department of Radiology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Sun, Lu, Tang, Yao, Sweeney, Gong, Lui); the Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Hu, Luo); the Chinese Evidence-Based Medicine Center and Cochrane China Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Wang); the Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, United States (Sweeney); the Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu); the Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China (Lui); the Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Lui).
Na Hu *From the Huaxi MR Research Center, Department of Radiology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Sun, Lu, Tang, Yao, Sweeney, Gong, Lui); the Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Hu, Luo); the Chinese Evidence-Based Medicine Center and Cochrane China Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Wang); the Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, United States (Sweeney); the Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu); the Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China (Lui); the Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Lui).
Mingqi WangFrom the Huaxi MR Research Center, Department of Radiology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Sun, Lu, Tang, Yao, Sweeney, Gong, Lui); the Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Hu, Luo); the Chinese Evidence-Based Medicine Center and Cochrane China Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Wang); the Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, United States (Sweeney); the Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu); the Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China (Lui); the Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Lui).
Lu LuFrom the Huaxi MR Research Center, Department of Radiology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Sun, Lu, Tang, Yao, Sweeney, Gong, Lui); the Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Hu, Luo); the Chinese Evidence-Based Medicine Center and Cochrane China Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Wang); the Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, United States (Sweeney); the Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu); the Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China (Lui); the Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Lui).
Chunyan LuoFrom the Huaxi MR Research Center, Department of Radiology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Sun, Lu, Tang, Yao, Sweeney, Gong, Lui); the Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Hu, Luo); the Chinese Evidence-Based Medicine Center and Cochrane China Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Wang); the Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, United States (Sweeney); the Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu); the Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China (Lui); the Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Lui).
Biqiu TangFrom the Huaxi MR Research Center, Department of Radiology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Sun, Lu, Tang, Yao, Sweeney, Gong, Lui); the Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Hu, Luo); the Chinese Evidence-Based Medicine Center and Cochrane China Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Wang); the Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, United States (Sweeney); the Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu); the Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China (Lui); the Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Lui).
Chenyang YaoFrom the Huaxi MR Research Center, Department of Radiology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Sun, Lu, Tang, Yao, Sweeney, Gong, Lui); the Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Hu, Luo); the Chinese Evidence-Based Medicine Center and Cochrane China Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Wang); the Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, United States (Sweeney); the Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu); the Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China (Lui); the Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Lui).
John A SweeneyFrom the Huaxi MR Research Center, Department of Radiology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Sun, Lu, Tang, Yao, Sweeney, Gong, Lui); the Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Hu, Luo); the Chinese Evidence-Based Medicine Center and Cochrane China Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Wang); the Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, United States (Sweeney); the Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu); the Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China (Lui); the Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Lui).
Qiyong GongFrom the Huaxi MR Research Center, Department of Radiology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Sun, Lu, Tang, Yao, Sweeney, Gong, Lui); the Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Hu, Luo); the Chinese Evidence-Based Medicine Center and Cochrane China Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Wang); the Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, United States (Sweeney); the Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu); the Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China (Lui); the Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Lui).
Changjian QiuFrom the Huaxi MR Research Center, Department of Radiology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Sun, Lu, Tang, Yao, Sweeney, Gong, Lui); the Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Hu, Luo); the Chinese Evidence-Based Medicine Center and Cochrane China Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Wang); the Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, United States (Sweeney); the Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu); the Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China (Lui); the Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Lui) qiuchangjian@wchscu.cn lusuwcums@hotmail.com.
Su LuiFrom the Huaxi MR Research Center, Department of Radiology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Sun, Lu, Tang, Yao, Sweeney, Gong, Lui); the Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Hu, Luo); the Chinese Evidence-Based Medicine Center and Cochrane China Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Wang); the Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, United States (Sweeney); the Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu); the Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China (Lui); the Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Lui) qiuchangjian@wchscu.cn lusuwcums@hotmail.com.
Sichuan University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNWest China Hospital of Sichuan University · CNUniversity of Cincinnati · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHippocampal disturbances are important in the pathophysiology of both schizophrenia and major depressive disorder (MDD). Imaging studies have shown selective volume deficits across hippocampal subfields in both disorders. We aimed to investigate whether these volumetric alterations in hippocampal subfields are shared or divergent across disorders.
methodsWe searched PubMed and Embase from database inception to May 8, 2021. We identified MRI studies in patients with schizophrenia, MDD or both, in which hippocampal subfield volumes were measured. We excluded nonoriginal, animal or postmortem studies, and studies that used other imaging modalities or overlapping data. We conducted a network meta-analysis to estimate and contrast alterations in subfield volumes in the 2 disorders.
resultsWe identified 45 studies that met the initial criteria for systematic review, of which 15 were eligible for network metaanalysis. Compared to healthy controls, patients with schizophrenia had reduced volumes in the bilateral cornu ammonis (CA) 1, granule cell layer of the dentate gyrus, subiculum, parasubiculum, molecular layer, hippocampal tail and hippocampus-amygdala transition area (HATA); in the left CA4 and presubiculum; and in the right fimbria. Patients with MDD had decreased volumes in the left CA3 and CA4 and increased volumes in the right HATA compared to healthy controls. The bilateral parasubiculum and right HATA were smaller in patients with schizophrenia than in patients with MDD. LIMITATIONS: We did not investigate medication effects because of limited information. Study heterogeneity was noteworthy in direct comparisons between patients with MDD and healthy controls.
conclusionThe volumes of multiple hippocampal subfields are selectively altered in patients with schizophrenia and MDD, with overlap and differentiation in subfield alterations across disorders. Rigorous head-to-head studies are needed to validate our findings.
Indexed as
Major Depressive DisorderSchizophreniaHippocampusHumansMagnetic Resonance ImagingOrgan Size
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