Evidence map›Paper›PMID 36749911›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2023

A leaky human colon model reveals uncoupled apical/basal cytotoxicity in early

Meryem T Ok, Jintong Liu, R Jarrett Bliton, Caroline M Hinesley, Ekaterina Ellyce T San Pedro, Keith A Breau, Ismael Gomez-Martinez, Joseph Burclaff, Scott T Magness

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 13 citations in OpenAlex.

  1. Building and regenerating intestines by manipulating intestinal stem cells.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  2. bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. A Shared Framework for Gastrointestinal Organoid Research: It's Time.Cellular and molecular gastroenterology and hepatology · 2026
    Article
  5. International journal of microbiology · 2026
    Article
  6. Article
  7. A scalable long-termbioRxiv : the preprint server for biology · 2025
    Article
  8. Infection and immunity · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Meryem T OkJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, United States.ORCID 0000-0001-6333-8891
Jintong LiuCenter for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, United States.
R Jarrett BlitonJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, United States.
Caroline M HinesleyCenter for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, United States.
Ekaterina Ellyce T San PedroCenter for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, United States.
Keith A BreauDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Ismael Gomez-MartinezDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Joseph BurclaffJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, United States.
Scott T MagnessJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, United States.ORCID 0000-0002-2746-1224
University of North Carolina at Chapel Hill · US

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
DEVELOPMENT OF HUMAN INTESTINAL SIMULACRAR01DK109559 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ALLBRITTON, NANCY L., BULTMAN, SCOTT J · 2015 to 2019
$5.2M
Genetic regulation of active and reserve intestinal stem cell statesR01DK115806 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAGNESS, SCOTT T · 2019 to 2022
$1.5M
Training Program in Cellular Systems and Integrative PhysiologyT32GM133364 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kathleen M Caron, Natasha T Snider · 2020 to 2026
$1.4M
A Novel Planar Crypt Microarray for Real-Time Evaluation of Human Intestinal Stem Cell FateF30DK126307 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OK, MERYEM TYRRASCH · 2020 to 2024
$180k
Determining the effects of Sox9 on the cell cycle of intestinal stem cellsF32DK124929 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BURCLAFF, JOSEPH R · 2021 to 2022
$91k
NIDDK NIH HHS F30 DK126307NIDDK NIH HHS F32 DK124929NIDDK NIH HHS P30 DK034987NIDDK NIH HHS R01 DK109559NIDDK NIH HHS R01 DK115806NIGMS NIH HHS T32 GM133364
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bacterial ToxinsClostridioides difficileBacterial ProteinsBoron CompoundsCaco-2 CellsColonDiclofenacDieldrinEnterotoxinsHumansBacterial ProteinsBacterial ToxinsBoron CompoundsDiclofenacDieldrinEnterotoxinsHCEtrimethylaminocarboxyldihydroboranabsorptive colonocyte monolayersintestinal stem cellspermeabilitytoxicity

Identifiers

PMID36749911
PMCPMC10010926
OpenAlexW4319338219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.