Evidence map›Paper›PMID 36749823›Full record

ArticleScience signaling2023

USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling.

Sara Kassel, Alison J Hanson, Hassina Benchabane, Kenyi Saito-Diaz, Carly R Cabel, Lily Goldsmith, Muhammad Taha, Aksheta Kanuganti, Victoria H Ng, George Xu and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science signaling, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
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  6. New insights in ubiquitin-dependent Wnt receptor regulation in tumorigenesis.In vitro cellular & developmental biology. Animal · 2024
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 2 countries.

Sara KasselDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-6612-4167
Alison J HansonDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-9498-1238
Hassina BenchabaneDepartment of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA.ORCID 0000-0003-0771-2249
Kenyi Saito-DiazDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-9829-2536
Carly R CabelDepartment of Cellular and Molecular Medicine, University of Arizona Cancer Center, Tucson, AZ 85724, USA.ORCID 0000-0001-9865-1810
Lily GoldsmithDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-3323-2428
Muhammad TahaDepartment of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA.ORCID 0000-0001-7272-1024
Aksheta KanugantiDepartment of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA.ORCID 0000-0002-1256-7173
Victoria H NgDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0003-2344-8468
George XuDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Fei YeDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0001-6472-5076
Julia PickerDepartment of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA.ORCID 0000-0003-3312-1645
Fillip PortGerman Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.ORCID 0000-0002-5157-4835
Michael BoutrosGerman Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.ORCID 0000-0002-9458-817X
Vivian L WeissDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0003-0874-3207
David J RobbinsDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.ORCID 0000-0003-0190-2973
Curtis A ThorneDepartment of Cellular and Molecular Medicine, University of Arizona Cancer Center, Tucson, AZ 85724, USA.ORCID 0000-0002-8711-8292
Yashi AhmedDepartment of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA.ORCID 0000-0002-7472-6010
Ethan LeeDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0001-8405-6156
Vanderbilt University · USDartmouth College · USVanderbilt University Medical Center · USGerman Cancer Research Center · DEUniversity of Arizona · USGeorgetown University · US

Funding

Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
Integrative Cancer Scholars Training GrantT32CA009213 · NCI · UNIVERSITY OF ARIZONA · PI CAREW, JENNIFER S, CURIEL-LEWANDROWSKI, CLARA · 1985 to 2024
$8.6M
TRAINING PROGRAM IN CELLULAR, BIOCHEMICAL, &MOLECULAR ST32GM008554 · NIGMS · VANDERBILT UNIVERSITY · PI PATTON, JAMES G. · 1995 to 2020
$7.4M
Mechanism of Wnt signal transductionR35GM122516 · NIGMS · VANDERBILT UNIVERSITY · PI ETHAN LEE · 2017 to 2026
$5.8M
Genetic and Molecular Dissection of Wnt Pathway ActivationSupplementR35GM136233 · NIGMS · DARTMOUTH COLLEGE · PI Yasmath Ahmed · 2020 to 2026
$4.5M
Inhibition of the Wnt Receptor Complex by the Tumor Suppressor Adenomatous Polyposis ColiR01CA244188 · NCI · DARTMOUTH COLLEGE · PI AHMED, YASMATH, LEE, ETHAN · 2020 to 2024
$3.2M
The Role of Cancer-Associated Fibroblasts in Thyroid CarcinomaR01CA272875 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WEISS, VIVIAN LEE · 2022 to 2025
$2.5M
Defining signaling networks in epithelial homeostasisR35GM147128 · NIGMS · UNIVERSITY OF ARIZONA · PI Curtis Andrew Thorne · 2022 to 2026
$2.0M
Targeting Wnt-dependent colorectal cancerR01CA219189 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ROBBINS, DAVID J · 2018 to 2022
$1.9M
The role of Wnt signaling in aggressive thyroid carcinomaK08CA240901 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WEISS, VIVIAN LEE · 2020 to 2024
$1.1M
The role of kinase signaling in intestinal epithelial homeostasisR00DK103126 · NIDDK · UNIVERSITY OF ARIZONA · PI THORNE, CURTIS ANDREW · 2018 to 2020
$747k
The role of kinase signaling in intestinal epithelial homeostasisK99DK103126 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI THORNE, CURTIS ANDREW · 2014 to 2015
$177k
NCI NIH HHS K08 CA240901NCI NIH HHS K12 CA090625NCI NIH HHS R01 CA219189NCI NIH HHS R01 CA244188NCI NIH HHS R01 CA272875NCI NIH HHS T32 CA009213NIDDK NIH HHS K99 DK103126NIDDK NIH HHS R00 DK103126NIEHS NIH HHS F30 ES016504NIGMS NIH HHS R35 GM122516NIGMS NIH HHS R35 GM136233NIGMS NIH HHS R35 GM147128NIGMS NIH HHS T32 GM008554
6 · The paper itself

Abstract

The Wnt-β-catenin signal transduction pathway is essential for embryonic development and adult tissue homeostasis. Wnt signaling converts TCF from a transcriptional repressor to an activator in a process facilitated by the E3 ligase XIAP. XIAP-mediated monoubiquitylation of the transcriptional corepressor Groucho (also known as TLE) decreases its affinity for TCF, thereby allowing the transcriptional coactivator β-catenin to displace it on TCF. Through a genome-scale screen in cultured

Indexed as

beta CateninWnt Signaling PathwayAnimalsCo-Repressor ProteinsDrosophilaDrosophila melanogasterHumansTranscription FactorsUbiquitin-Protein LigasesUbiquitin-Specific ProteasesUbiquitin ThiolesteraseXenopusbeta CateninCo-Repressor ProteinsTLE3 protein, humanTranscription FactorsUbiquitin-Protein LigasesUbiquitin-Specific ProteasesUbiquitin ThiolesteraseUSP47 protein, human

Identifiers

PMID36749823
PMCPMC10038201
OpenAlexW4319342186

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.