ArticleProceedings of the National Academy of Sciences of the United States of America2023
Behavioral encoding across timescales by region-specific dopamine dynamics.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- It's not all DAT: harnessing the potential of organic cation transporter 3 inhibition to selectively attenuate amphetamine reinforcement and dopamine release.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- Dopamine Dynamics in the Nucleus Accumbens Reflect Confidence in Detecting the Occurrence and Nonoccurrence of Visual Signals in Perceptual Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Mouse model of atypical DAT deficiency syndrome uncovers dopamine dysfunction associated with parkinsonism and ADHD.The Journal of clinical investigation · 2026Article
- Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum.eLife · 2026Article
- An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement.bioRxiv : the preprint server for biology · 2026Article
- Rebound Bursting Selectively Enables Fast Dynamics in Dopamine Midbrain Neurons Projecting to the Dorsolateral Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Kappa opioid receptor antagonism restores phosphorylation, trafficking and behavior induced by a disease-associated dopamine transporter variant.Molecular psychiatry · 2025Article
- Kappa opioid receptors diminish spontaneous dopamine signals in awake mice through multiple mechanisms.Neuropharmacology · 2025Article
- PASTa: An Open-Source Analysis and Signal Processing Toolbox for Fiber Photometry Data.Current protocols · 2025Article
- Evaluation of unsupervised learning algorithms for the classification of behavior from pose estimation data.Patterns (New York, N.Y.) · 2025Article
- Regulation of Dopamine Release by Tonic Activity Patterns in the Striatal Brain Slice.ACS chemical neuroscience · 2025Article
- Striosome Circuitry Stimulation Inhibits Striatal Dopamine Release and Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neuromodulator and neuropeptide sensors and probes for precise circuit interrogation in vivo.Science (New York, N.Y.) · 2024Review
- Dopaminergic Neurons in Zona Incerta Drives Appetitive Self-Grooming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Spatially organized striatal neuromodulator release encodes trajectory errors.bioRxiv : the preprint server for biology · 2024Article
- Disruption of positive- and negative-feature morphine interoceptive occasion setters by dopamine receptor agonism and antagonism in male and female rats.Psychopharmacology · 2024Article
- A chemogenetic approach for dopamine imaging with tunable sensitivity.Nature communications · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dorsal (DS) and ventral striatum (VS) receive dopaminergic projections that control motor functions and reward-related behavior. It remains poorly understood how dopamine release dynamics across different temporal scales in these regions are coupled to behavioral outcomes. Here, we employ the dopamine sensor dLight1.3b together with multiregion fiber photometry and machine learning-based analysis to decode dopamine dynamics across the striatum during self-paced exploratory behavior in mice. Our data show a striking coordination of rapidly fluctuating signal in the DS, carrying information across dopamine levels, with a slower signal in the VS, consisting mainly of slow-paced transients. Importantly, these release dynamics correlated with discrete behavioral motifs, such as turns, running, and grooming on a subsecond-to-minute time scale. Disruption of dopamine dynamics with cocaine caused randomization of action selection sequencing and disturbance of DS-VS coordination. The data suggest that distinct dopamine dynamics of DS and VS jointly encode behavioral sequences during unconstrained activity with DS modulating the stringing together of actions and VS the signal to initiate and sustain the selected action.
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