Evidence map›Paper›PMID 36749645›Full record

ArticleACS applied bio materials2023

Development of a Slow-Degrading Polymerized Curcumin Coating for Intracortical Microelectrodes.

Alexis M Ziemba, Mary Clare Crochiere Woodson, Jessica L Funnell, Douglas Wich, Bailey Balouch, Deniz Rende, Dahlia N Amato, Jonathan Bao, Ingrid Oprea, Dominica Cao and 5 more

Open access · greenAbstract read
In one paragraph

Article in ACS applied bio materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Poly(curcumin-Journal of neural engineering · 2025
    Article
  8. Article
  9. Effects of Micromachining on Anti-oxidant Elution from a Mechanically-Adaptive Polymer.Journal of micromechanics and microengineering : structures, devices, and systems · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Alexis M ZiembaDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
Mary Clare Crochiere WoodsonDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
Jessica L FunnellDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
Douglas WichDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
Bailey BalouchCenter for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
Deniz RendeCenter for Materials, Devices, and Integrated Systems, Rensselaer Polytechnic Institute, 110 8th Street, Troy 12180-3590, New York, United States.
Dahlia N AmatoDepartment of Materials Science and Engineering, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
Jonathan BaoCenter for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
Ingrid OpreaCenter for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
Dominica CaoNeuroscience Program, Department of Biological Sciences, Smith College, Northampton 01063, Massachusetts, United States.
Neda BajaloCenter for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
Evon S EreifejVeteran Affairs Ann Arbor Healthcare System, Ann Arbor 48104, Michigan, United States.
Jeffrey R CapadonaUnited States Advanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland 44106, Ohio, United States.
Edmund F PalermoDepartment of Materials Science and Engineering, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.ORCID 0000-0003-3656-787X
Ryan J GilbertDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.ORCID 0000-0002-3501-6753
Rensselaer Polytechnic Institute · USLouis Stokes Cleveland VA Medical Center · USSmith College · USUniversity of Michigan · US

Funding

Enhanced Neuroprotection Following Acute SCI Using Fibrous MaterialsR01NS092754 · NINDS · RENSSELAER POLYTECHNIC INSTITUTE · PI GILBERT, RYAN J. · 2015 to 2019
$1.3M
NINDS NIH HHS R01 NS092754RRD VA IK2 RX002628
6 · The paper itself

Abstract

Intracortical microelectrodes are used with brain-computer interfaces to restore lost limb function following nervous system injury. While promising, recording ability of intracortical microelectrodes diminishes over time due, in part, to neuroinflammation. As curcumin has demonstrated neuroprotection through anti-inflammatory activity, we fabricated a 300 nm-thick intracortical microelectrode coating consisting of a polyurethane copolymer of curcumin and polyethylene glycol (PEG), denoted as poly(curcumin-PEG

Indexed as

CurcuminAnimalsElectrodes, ImplantedMicroelectrodesNeuronsPolymersRatsCurcuminPolymerscoatingcurcumindrug deliveryelectrodepolyethylene glycolpolyprodrug

Identifiers

PMID36749645
PMCPMC11366415
OpenAlexW4319332976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.