Evidence map›Paper›PMID 36749608›Full record

ArticleEnvironmental health perspectives2023

Associations of Prenatal Chemical and Nonchemical Stressors with Early-Adulthood Anxiety and Depressive Symptoms.

Lisa B Rokoff, Brent A Coull, Michelle Bosquet Enlow, Susan A Korrick

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Lisa B RokoffDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0003-2147-0397
Brent A CoullDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Michelle Bosquet EnlowDepartment of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, Massachusetts, USA.
Susan A KorrickDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Harvard University · USBoston Children's Hospital · USBrigham and Women's Hospital · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
VANADIUM AND HUMAN HEALTHP42ES005947 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KELSEY, KARL TIMOTHY · 1992 to 2006
$19.6M
Metal and Organochlorines Exposure: Impact on Adolescent Behavior and CognitionR01ES014864 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI KORRICK, SUSAN A · 2006 to 2010
$3.3M
Environmental risk factors for autistic behaviors in a cohort studyR21ES024513 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI KORRICK, SUSAN A · 2015 to 2016
$503k
ACL HHS T42OH008416NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P42 ES005947NIEHS NIH HHS R01 ES014864NIEHS NIH HHS R21 ES024513NIOSH CDC HHS T42 OH008416
6 · The paper itself

Abstract

backgroundPrenatal exposure to environmental chemicals may increase risk of childhood internalizing problems, but few studies have explored the potential for longer-term consequences of such exposures.

objectiveWe evaluated associations between prenatal organochlorine and metal levels and early adulthood internalizing symptoms, considering whether sociodemographic/nonchemical stressors modified these associations.

methodsParticipants were 209 young adults, born (1993-1998) to mothers residing in or near New Bedford, Massachusetts. As part of the early-adult assessment, self-reported anxiety (7-item Generalized Anxiety Disorder scale) and depressive (8-item Patient Health Questionnaire) symptoms (

resultsParticipants were ( DISCUSSION: Prenatal organochlorine pesticides and lead exposure possibly increases risk of internalizing problems, particular anxiety symptoms, in young adults. Varying risk was observed by sociodemographic/nonchemical stressor strata, demonstrating the importance of considering interactions between chemical and other stressors. https://doi.org/10.1289/EHP11171.

Indexed as

Environmental PollutantsHydrocarbons, ChlorinatedPolychlorinated BiphenylsPrenatal Exposure Delayed EffectsAdolescentAdultAnxietyDepressionDichlorodiphenyl DichloroethyleneEnvironmental ExposureFemaleHexachlorobenzeneHumansInfant, NewbornMaleManganeseDichlorodiphenyl DichloroethyleneEnvironmental PollutantsHexachlorobenzeneHydrocarbons, ChlorinatedManganesePolychlorinated Biphenyls

Identifiers

PMID36749608
PMCPMC9904409
OpenAlexW4319334123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.