Evidence map›Paper›PMID 36749044›Full record

ArticlemSphere2023

Role of the Mycobacterium tuberculosis ESX-4 Secretion System in Heme Iron Utilization and Pore Formation by PPE Proteins.

November Sankey, Haley Merrick, Padam Singh, Janet Rogers, Amit Reddi, Steven D Hartson, Avishek Mitra

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Epigenetic Reprogramming byAntibiotics (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. ThemBio · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Loss of the ESX-5 secretion locus inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Heme and immunity: The heme oxygenase dichotomy.Journal of inorganic biochemistry · 2025
    Review
  16. Atomic-level binding interaction analysis ofIn silico pharmacology · 2025
    Article
  17. The PE/PPE family proteins ofFrontiers in immunology · 2025
    Review
  18. Article
  19. Article
  20. PE/PPE Proteome and ESX-5 Substrate Spectrum inInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

November SankeyDepartment of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, Oklahoma, USA.
Haley MerrickDepartment of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, Oklahoma, USA.
Padam SinghDepartment of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, Oklahoma, USA.
Janet RogersDepartment of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, USA.
Amit ReddiSchool of Chemistry and Biochemistry, Parker Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia, USA.ORCID 0000-0003-3952-404X
Steven D HartsonDepartment of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, USA.
Avishek MitraDepartment of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, Oklahoma, USA.ORCID 0000-0003-0243-2045
Oklahoma State University · USGeorgia Institute of Technology · US

Funding

Vascular-macrophage crosstalk in GBM immunosuppressionP20GM134973 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Jimmy D. Ballard · 2020 to 2026
$17.6M
Illuminating Heme Trafficking and Signaling Pathways in Health and DiseaseR35GM145350 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Amit Ram Reddi · 2022 to 2026
$1.9M
NIGMS NIH HHS P20 GM134973NIGMS NIH HHS R35 GM145350
6 · The paper itself

Abstract

Mycobacterium tuberculosis (

Indexed as

Mycobacterium tuberculosisType VII Secretion SystemsBacterial ProteinsHemeHumansIronMembrane ProteinsPersonal Protective EquipmentBacterial ProteinsHemeIronMembrane ProteinsType VII Secretion SystemsESX-4hemeheme transportiron acquisitionmembrane channel proteinsMycobacterium tuberculosismycomembranemycomembrane channel proteinouter membranePPEtype VII secretion

Identifiers

PMID36749044
PMCPMC10117145
OpenAlexW4319334262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.