Evidence map›Paper›PMID 36748946›Full record

ArticleNanomedicine (London, England)2022

Effective treatment of retinal neovascular leakage with fusogenic porous silicon nanoparticles delivering VEGF-siRNA.

Joel F Grondek, Kristyn Huffman, Ella Jiyoon Lee, Melina Cavichini, Alexandra Warter, Fritz Gerald P Kalaw, Anna Heinke, Ruhan Fan, Lingyun Cheng, Michael J Sailor and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Available Therapeutic Options for Corneal Neovascularization: A Review.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Joel F GrondekDepartment of Chemistry & Biochemistry, University of California, San Diego, CA 92093, USA.ORCID 0000-0002-6386-3423
Kristyn HuffmanDepartment of Ophthalmology, Jacobs Retinal Center at Shiley Eye Institute, University of California, San Diego, CA 92093, USA.
Ella Jiyoon LeeDepartment of Chemistry & Biochemistry, University of California, San Diego, CA 92093, USA.
Melina CavichiniDepartment of Ophthalmology, Jacobs Retinal Center at Shiley Eye Institute, University of California, San Diego, CA 92093, USA.
Alexandra WarterDepartment of Ophthalmology, Jacobs Retinal Center at Shiley Eye Institute, University of California, San Diego, CA 92093, USA.
Fritz Gerald P KalawDepartment of Ophthalmology, Jacobs Retinal Center at Shiley Eye Institute, University of California, San Diego, CA 92093, USA.
Anna HeinkeDepartment of Ophthalmology, Jacobs Retinal Center at Shiley Eye Institute, University of California, San Diego, CA 92093, USA.
Ruhan FanMaterials Science & Engineering, University of California, San Diego, CA 92093, USA.
Lingyun ChengDepartment of Ophthalmology, Jacobs Retinal Center at Shiley Eye Institute, University of California, San Diego, CA 92093, USA.
Michael J SailorDepartment of Chemistry & Biochemistry, University of California, San Diego, CA 92093, USA.
William R FreemanDepartment of Ophthalmology, Jacobs Retinal Center at Shiley Eye Institute, University of California, San Diego, CA 92093, USA.
University of California San Diego · US

Funding

Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2012 to 2026
$10.3M
Mechanistic-Based Non-Invasive Assessment of Retinal Damage in HAART EraR01EY016323 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BARTSCH, DIRK-UWE G · 2006 to 2020
$5.0M
SCH: Multimodal Retina Image Alignment and ApplicationsR01EY033847 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AN, CHEOLHONG, BARTSCH, DIRK-UWE G · 2021 to 2024
$1.2M
NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY016323NEI NIH HHS R01 EY033847NIH HHS P30EY022589, R01 EY016323 DUB, R01 EY033847-01 WRF
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Diabetic RetinopathyMacular EdemaNanoparticlesRetinal NeovascularizationAnimalsIntravitreal InjectionsLipidsPorosityRabbitsRNA, Small InterferingSiliconVascular Endothelial Growth Factor ALipidsRNA, Small InterferingSiliconVascular Endothelial Growth Factor Adiabetic retinopathyfusogeniciRGDporous silicon nanoparticlesiRNAVEGF

Identifiers

PMID36748946
PMCPMC10031552
OpenAlexW4319334330

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.