Evidence map›Paper›PMID 36748523›Full record

ArticleMicrobiology (Reading, England)2023

Do mitochondria use efflux pumps to protect their ribosomes from antibiotics?

Md Deen Islam, Brian D Harrison, Judy J-Y Li, Austein G McLoughlin, Deborah A Court

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology (Reading, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Frontiers in microbiology · 2026
    Article
  2. Article
  3. Microbial Musings: Winter 2023.Microbiology (Reading, England) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Md Deen IslamDepartment of Microbiology, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.
Brian D HarrisonDepartment of Microbiology, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.
Judy J-Y LiDepartment of Microbiology, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.
Austein G McLoughlinDepartment of Microbiology, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.
Deborah A Court
University of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungal environments are rich in natural and engineered antimicrobials, and this, combined with the fact that fungal genomes are rich in coding sequences for transporters, suggests that fungi are an intriguing group in which to search for evidence of antimicrobial efflux pumps in mitochondria. Herein, the range of protective mechanisms used by fungi against antimicrobials is introduced, and it is hypothesized, based on the susceptibility of mitochondrial and bacterial ribosomes to the same antibiotics, that mitochondria might also contain pumps that efflux antibiotics from these organelles. Preliminary evidence of ethidium bromide efflux is presented and several candidate efflux pumps are identified in fungal mitochondrial proteomes.

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsBiological TransportMembrane Transport ProteinsMitochondriaRibosomesAnti-Bacterial AgentsAnti-Infective AgentsMembrane Transport ProteinsABC transportersMFS transportersmitochondria drug effluxmitochondrial ribosomesNeurospora crassaSaccharomyces cerevisiae

Identifiers

PMID36748523
PMCPMC9993110
OpenAlexW4317390088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.