Evidence map›Paper›PMID 36748513›Full record

ArticleThe Journal of general virology2022

Suppression of innate immunity by the vaccinia virus protein N1 promotes skin microbiota expansion and increased immune infiltration following vaccination.

Evgeniya V Shmeleva, Danial Syafiq, Ana L Moldoveanu, Brian J Ferguson, Geoffrey L Smith

Open access · hybridAbstract read
In one paragraph

Article in The Journal of general virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Evgeniya V ShmelevaDepartment of Pathology, University of Cambridge, Cambridge, UK.
Danial SyafiqDepartment of Pathology, University of Cambridge, Cambridge, UK.
Ana L MoldoveanuDepartment of Pathology, University of Cambridge, Cambridge, UK.
Brian J FergusonDepartment of Pathology, University of Cambridge, Cambridge, UK.
Geoffrey L SmithDepartment of Pathology, University of Cambridge, Cambridge, UK.
University of Cambridge · GBTufts University · US

Funding

Medical Research Council MR/M019810/1Wellcome TrustWellcome Trust 090315
6 · The paper itself

Abstract

Vaccinia virus (VACV) protein N1 is an intracellular immunomodulator that contributes to virus virulence via inhibition of NF-κB. Intradermal infection with a VACV lacking gene

Indexed as

Immunity, InnateSkinVacciniaVaccinia virusViral ProteinsHumansImmunologic FactorsMicrobiotaVaccinationImmunologic FactorsN1L protein, Vaccinia virusViral Proteinsinnate immunityN1NF-κBskin microbiotaVaccinia virus

Identifiers

PMID36748513
PMCPMC7614846
OpenAlexW4309827681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.