ReviewEuropean endodontic journal2023
The Paradigm of the Inflammatory Radicular Cyst: Biological Aspects to be Considered.
Review in European endodontic journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- A comparison of piezoelectric surgery and conventional techniques in the enucleation of cysts and tumors in the jaws: a systematic review and meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2025Pooled it
- Accuracy of Ultrasound Imaging in the Differential Diagnosis of Inflammatory Radicular Cyst and Periapical Granuloma: A Systematic Review and Meta-Analysis of Operative Characteristics.European endodontic journal · 2025Pooled it
- A Comparative Study of Caerin 1.1/1.9 and Calcium Hydroxide in the Treatment of Apical Periodontitis in Rats.International dental journal · 2026Article
- Gingival cysts of the adult associated with gingival inflammation hyperplasia: a rare case report.BMC oral health · 2026Article
- Initial attachment, viability, proliferation, and migration of osteoblast-like SaOS-2 cells on two resorbable xenogeneic membranes for guided tissue regeneration: ab in vitro experimental study.Restorative dentistry & endodontics · 2026Article
- Biological mechanisms underlying the inflammatory radicular cyst formation-focus on epithelial proliferation: a systematic review of experimental cell and tissue models.Restorative dentistry & endodontics · 2026Article
- Surgical Management of a Large Radicular Cyst in a Maxillary Incisor Following Failed Regenerative Endodontics and Apical Plug in an Adolescent: A Case Report.Case reports in dentistry · 2026Article
- Panoramic radiographic prevalence of dental developmental anomalies and jaw lesions in Mallorca, Spain: a retrospective cross-sectional study.Frontiers in oral health · 2026Article
- Serum metabolomics identifies biomarkers in radicular cysts.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Radiographic and Clinical Outcomes of Laser-Enhanced Disinfection in Endodontic Therapy.Journal of clinical medicine · 2025Article
- Evaluation of Vitamin D and of Some Biomarkers of Bone Remodelling (CTX-1, Osteocalcin, BALP) in Subjects with Periapical Inflammatory Cysts: An Observational Study.Journal of clinical medicine · 2025Article
- Histological and immunohistochemical analysis of human periapical lesions: a study of TGF-β1 and CD68 markers.BMC oral health · 2025Article
- Integrated metagenomics and transcriptomics analysis reveals pathways associated with oral periapical lesions formation and progression.Current research in microbial sciences · 2025Article
- Assessing the efficacy of apicoectomy without retrograde filling in treating periapical inflammatory cysts.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2024Article
- About a Possible Impact of Endodontic Infections byInternational journal of molecular sciences · 2024Review
- A case of radicular cyst on deciduous tooth in a 7-year-old child.Oral radiology · 2024Article
- Outcome of nonsurgical management of large cyst-like periapical lesions using a modified apical negative pressure irrigation system: a case series study.BMC oral health · 2024Observational
- Microsurgical management of radicular cyst using guided tissue regeneration technique: A case report.World journal of clinical cases · 2024Article
- TLR4 expression and its immunopathogenic role in inflammatory radicular cysts: a clinicopathological study.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
- Vascular remodeling and microvessel density in inflammatory radicular cysts: a CD34 immunohistochemical analysis.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory radicular cysts (IRCs) are chronic lesions that follow the development of periapical granulomas (PGs). IRCs result from multiple inflammatory reactions led initially by several pro-inflammatory interleukins and growth factors that provoke the proliferation of epithelial cells derived from epithelial cell rests of Malassez present in the granulomatous tissue, followed by cyst formation and growth processes. Multiple theories have been proposed to help explain the molecular process involved in the development of the IRC from a PG. However, although multiple studies have demonstrated the presence of epithelial cells in most PGs, it is still not fully understood why not all PGs turn into IRCs, even though both are stages of the same inflammatory phenomenon and receive the same antigenic stimulus. Histopathological examination is currently the diagnostic gold standard for differentiating IRCs from PGs. Although multiple studies have evaluated the accuracy of non-invasive or minimally invasive methods in assessing the histopathological nature of the AP before the intervention, these studies' results are still controversial. This narrative review addresses the biological insights into the complex molecular mechanisms of IRC formation and its histopathological features. In addition, the relevant inflammatory molecular mediators for IRC development and the accuracy of non-invasive or minimally invasive diagnostic approaches are summarised. (EEJ-2022-03-041).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.