Evidence map›Paper›PMID 36748341›Full record

ArticleActa crystallographica. Section F, Structural biology communications2023

Purification and structure of luminal domain C of human Niemann-Pick C1 protein.

Laura Odongo, Kaneil K Zadrozny, William E Diehl, Jeremy Luban, Judith M White, Barbie K Ganser-Pornillos, Lukas K Tamm, Owen Pornillos

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta crystallographica. Section F, Structural biology communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Other Techniques.Advances in biochemical engineering/biotechnology · 2026
    Review
  2. Article
  3. A novelMicrobiology spectrum · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Laura OdongoCenter for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA 22908, USA.
Kaneil K ZadroznyCenter for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA 22908, USA.
William E DiehlProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Jeremy LubanProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Judith M WhiteCenter for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA 22908, USA.
Barbie K Ganser-PornillosCenter for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA 22908, USA.
Lukas K TammCenter for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA 22908, USA.
Owen PornillosCenter for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA 22908, USA.
University of Virginia · USUniversity of Massachusetts Chan Medical School · US

Funding

VIRAL SPIKE GLYCOPROTEIN-MEDIATED MEMBRANE POTENTIALR01AI030557 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI TAMM, LUKAS K · 1991 to 2022
$6.2M
Insight into the Ebola virus glycoprotein fusion mechanism gleaned from the 2013-2016 epidemic GP-A82V variantR01AI148784 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUBAN, JEREMY · 2020 to 2024
$4.1M
NIAID NIH HHS R01 AI030557NIAID NIH HHS R01 AI148784
6 · The paper itself

Abstract

Niemann-Pick C1 protein (NPC1) is a membrane protein that primarily resides in late endosomes and lysosomes, and plays an important role in cholesterol homeostasis in the cell. The second luminal domain of NPC1 (NPC1-C) serves as the intracellular receptor for Ebola and Marburg viruses. Here, the recombinant production of nonglycosylated and glycosylated NPC1-C and a new crystal form of the nonglycosylated protein are reported. The crystals belonged to space group P2

Indexed as

Membrane GlycoproteinsNiemann-Pick C1 ProteinCrystallography, X-RayGlycoproteinsHumansIntracellular Signaling Peptides and ProteinsLysosomesGlycoproteinsIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsNiemann-Pick C1 ProteincholesterolEbola virusmembrane proteinsNiemann–Pick C1 protein

Identifiers

PMID36748341
PMCPMC9903137
OpenAlexW4318984769

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.