Evidence map›Paper›PMID 36748334›Full record

ArticleJournal of genetic counseling2023

Measuring high-risk parents' opinions about direct-to-consumer genetic testing for adult-onset inherited cancer syndromes in their adolescent and young adult children.

Emily Hasser, Beth N Peshkin, Jada G Hamilton, Jamie Brower, Hannah Ovadia, Lainie Friedman Ross, Rosalba Sacca, Beth Tarini, Susan M Domchek, Sarah Vittone and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of genetic counseling, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Emily HasserUniversity of Washington, Seattle, Washington, USA.
Beth N PeshkinGeorgetown University, Washington, District of Columbia, USA.
Jada G HamiltonMemorial Sloan Kettering Cancer Center, New York, New York, USA.
Jamie BrowerUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Hannah OvadiaMemorial Sloan Kettering Cancer Center, New York, New York, USA.
Lainie Friedman RossThe University of Chicago, Chicago, Illinois, USA.
Rosalba SaccaMemorial Sloan Kettering Cancer Center, New York, New York, USA.
Beth TariniChildren's National Health System, Washington, District of Columbia, USA.
Susan M DomchekUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Sarah VittoneGeorgetown University, Washington, District of Columbia, USA.
Marcelo SleimanGeorgetown University, Washington, District of Columbia, USA.
Claudine IsaacsGeorgetown University, Washington, District of Columbia, USA.
Sarah KnerrUniversity of Washington, Seattle, Washington, USA.
Benjamin S WilfondUniversity of Washington, Seattle, Washington, USA.
Kenneth P TercyakGeorgetown University, Washington, District of Columbia, USA.
Georgetown University · USMemorial Sloan Kettering Cancer Center · USUniversity of Washington · USUniversity of Pennsylvania · USChildren's National · USUniversity of Chicago · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
Improving Genetic Counseling for BRCA+ MothersR01CA246589 · NCI · GEORGETOWN UNIVERSITY · PI PESHKIN, BETH N, TERCYAK, KENNETH · 2020 to 2024
$2.0M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA051008NCI NIH HHS R01 CA246589
6 · The paper itself

Abstract

Neither direct-to-consumer (DTC) genetic testing nor predictive genetic testing for adult-onset conditions is recommended for minor children due to ethical concerns and low clinical utility. However, parents with pathogenic variants (PVs) in disease-causing genes may be interested in pursuing genetic testing that includes the familial PV for their children. The Pediatric Testing Attitudes Scale (P-TAS) was previously developed to examine high-risk parents' opinions about pediatric BRCA genetic testing for adult-onset breast/ovarian cancer. Here, the psychometric properties of the P-TAS were examined in a new sample of N = 126 parents (M age = 47.2 years) with PVs in a more complete set of cancer risk genes represented on DTC panel tests. The mean score on the P-TAS was 44 out of a maximum score of 60, indicating that a majority of parents generally held favorable opinions about testing their children for adult-onset inherited cancer syndromes. The internal consistency of the full scale was high (α = 0.91). A factor analysis identified two-component scales, labeled Attitudes and Beliefs (α = 0.93) and Decision Making and Communication (α = 0.83). In a multivariable regression model, P-TAS co-factors accounted for 34% of variance in parental opinions, including the frequency of prior family communication about cancer and the likelihood of utilizing DTC genetic testing with children (R

Indexed as

Breast NeoplasmsNeoplastic Syndromes, HereditaryAdolescentAdult ChildrenAttitudeChildFemaleGenetic CounselingGenetic TestingHumansMiddle AgedParentsYoung Adultassessmentcancerchildrendirect-to-consumer genetic testinggenetic counselingparents

Identifiers

PMID36748334
PMCPMC10404634
OpenAlexW4319333582

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.