ArticleThe Plant cell2023
Anisotropic cell growth at the leaf base promotes age-related changes in leaf shape in Arabidopsis thaliana.
Article in The Plant cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- A multiscale growth atlas of Arabidopsis: linking cell dynamics to organ development.The New phytologist · 2026Pooled it
- Evolutionary History, Transcriptome Expression Profiles, and Abiotic Stress Responses of theInternational journal of molecular sciences · 2026Article
- A common pathway controls cell size in the sepal and leaf epidermis leading to a nonrandom pattern of giant cells.PLoS biology · 2025Article
- Cytokinin depends on GA biosynthesis and signaling to regulate different aspects of vegetative phase change in Arabidopsis.Nature communications · 2025Article
- Redundant functions of miR156-targeted SQUAMOSA PROMOTER BINDING PROTEIN-LIKE transcription factors in promoting cauline leaf identity.The New phytologist · 2025Article
- Modulation of cell differentiation and growth underlies the shift from bud protection to light capture in cauline leaves.Plant physiology · 2024Article
- Genetic Evidence ofGenes · 2024Article
- Leaf form diversity and evolution: a never-ending story in plant biology.Journal of plant research · 2024Review
- Anatomical Mechanisms of Leaf Blade Morphogenesis inPlants (Basel, Switzerland) · 2024Article
- Temporal regulation of vegetative phase change in plants.Developmental cell · 2024Review
- RcSPL1-RcTAF15b regulates the flowering time of rose (Horticulture research · 2023Article
- Shape-shifting leaves depend on SPL10.The Plant cell · 2023Article
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9 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Plants undergo extended morphogenesis. The shoot apical meristem (SAM) allows for reiterative development and the formation of new structures throughout the life of the plant. Intriguingly, the SAM produces morphologically different leaves in an age-dependent manner, a phenomenon known as heteroblasty. In Arabidopsis thaliana, the SAM produces small orbicular leaves in the juvenile phase, but gives rise to large elliptical leaves in the adult phase. Previous studies have established that a developmental decline of microRNA156 (miR156) is necessary and sufficient to trigger this leaf shape switch, although the underlying mechanism is poorly understood. Here we show that the gradual increase in miR156-targeted SQUAMOSA PROMOTER BINDING PROTEIN-LIKE transcription factors with age promotes cell growth anisotropy in the abaxial epidermis at the base of the leaf blade, evident by the formation of elongated giant cells. Time-lapse imaging and developmental genetics further revealed that the establishment of adult leaf shape is tightly associated with the longitudinal cell expansion of giant cells, accompanied by a prolonged cell proliferation phase in their vicinity. Our results thus provide a plausible cellular mechanism for heteroblasty in Arabidopsis, and contribute to our understanding of anisotropic growth in plants.
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