Evidence map›Paper›PMID 36748063›Full record

ArticleBiochemistry and biophysics reports2023

The role of complement C3 in the outcome of regional myocardial infarction.

Zhou Fang, Xiang Li, Junying Liu, Haekyung Lee, Louis Salciccioli, Jason Lazar, Ming Zhang

Open access · goldAbstract read
In one paragraph

Article in Biochemistry and biophysics reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zhou FangDepartment of Anesthesiology, USA.
Xiang LiDepartment of Anesthesiology, USA.
Junying LiuDepartment of Anesthesiology, USA.
Haekyung LeeDepartment of Anesthesiology, USA.
Louis SalciccioliDepartment of Medicine, SUNY Downstate Health Science University, 450 Clarkson Avenue, Brooklyn, NY, 11203, USA.
Jason LazarDepartment of Medicine, SUNY Downstate Health Science University, 450 Clarkson Avenue, Brooklyn, NY, 11203, USA.
Ming ZhangDepartment of Anesthesiology, USA.
SUNY Downstate Health Sciences University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary heart disease leading to myocardial ischemia is a major cause of heart failure. A hallmark of heart failure is myocardial fibrosis. Using a murine model of myocardial ischemia/reperfusion injury (IRI), we showed that, following IRI, in mice genetically deficient in the central factor of complement system, C3, myocardial necrosis was reduced compared with WT mice. Four weeks after the ischemic period, the C3

Indexed as

C4BP, C4 binding proteinCardiac fibrosis. 1Complement C3DTBT, door-to-balloon timeFB, Factor BFH, Factor FFI, Factor IIRI, ischemia/reperfusion injuryIR, ischemia/reperfusionIschemia/reperfusion injury (IRI)MBL, mannose binding lectinNecrosisTCC, terminal complement complex

Identifiers

PMID36748063
PMCPMC9898614
OpenAlexW4318035330

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.