Evidence map›Paper›PMID 36748059›Full record

ArticleCase reports in neurology

COVID-19-Associated Cerebrovascular Events: A Case Series Study and a Literature Review of Possible Mechanisms.

Mostafa Meshref, Ibrahim M Hewila, Yahia Khlidj, Rafik Korissi, Nour Shaheen, Abdulqadir J Nashwan, Yassamine Ouerdane, Yara Amro, Khaled M Taher, Mahmoud Galal Ahmed

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 5 countries.

Mostafa MeshrefNeurology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ibrahim M HewilaNeurology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Yahia KhlidjFaculty of Medicine, University of Algiers Benyoucef Benkhedda, Algiers, Algeria.
Rafik KorissiFaculty of Medicine, University of Algiers Benyoucef Benkhedda, Algiers, Algeria.
Nour ShaheenAlexandria Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Abdulqadir J NashwanHamad Medical Corporation, Doha, Qatar.
Yassamine OuerdaneFaculty of Medicine, Saad Dahlab University, Blida, Algeria.
Yara AmroPharmacist, Ministry of Health, Cairo, Egypt.
Khaled M TaherNeurology Department, King Khaled Hospital, Najran, Saudi Arabia.
Mahmoud Galal AhmedNeurology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Al-Azhar University · EGUniversity of Algiers Benyoucef Benkhedda · DZAlexandria University · EGHamad Medical Corporation · QAKing Khaled Hospital · SAUniversity of Blida · DZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects multiple body systems, including the nervous system. Cerebrovascular accidents can also occur. Patients with comorbid illnesses have severe manifestations and poor outcomes. Despite the proper mechanism of SARS-CoV-2 infection-associated stroke having not yet been settled, various possible mechanisms have been hypothesized. One possibility is that the virus causes endothelial dysfunction and immune-mediated injury. Another possibility is that the trans-neuronal spread of the virus affects brain tissue. In addition, hypercoagulability caused by SARS-CoV-2 infection could lead to a stroke. A virus-induced dysfunction of the renin-angiotensin system could also lead to a stroke. The immune response and vasculitis resulting from SARS-CoV-2 infection are also possible causes via a cytokine storm, immune dysfunction, and various inflammatory responses. SARS-CoV-2 infection may affect calcitonin gene-related peptides and cerebral blood flow and may lead to stroke. Finally, SARS-CoV-2 may cause hemorrhagic strokes via mechanisms stimulated by its interaction with angiotensin-converting enzyme 2 (ACE2), leading to arterial wall damage and blood pressure changes. In this article, we will present seven cases of stroke-associated SARS-CoV-2 infection.

Indexed as

Cytokine stormHemorrhagic strokeImmune dysfunctionSevere acute respiratory syndrome coronavirus 2Stroke

Identifiers

PMID36748059
PMCPMC9898811
OpenAlexW4319068010

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.