Evidence map›Paper›PMID 36748010›Full record

ArticleInternational journal of hepatology2023

Liver Injury Patterns and Hepatic Toxicity among People Living with and without HIV and Attending Care in Urban Uganda.

Clara Wekesa, Rosalind Parkes-Ratanshi, Gregory D Kirk, Ponsiano Ocama

Open access · goldAbstract read
In one paragraph

Article in International journal of hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Clara WekesaInfectious Diseases Institute, Makerere University, Kampala, Uganda.ORCID https://orcid.org/0000-0001-6064-237X
Rosalind Parkes-RatanshiCambridge University, Institute of Public Health, Cambridge, UK.
Gregory D KirkJohn Hopkins University, Baltimore, USA.
Ponsiano OcamaCollege of Health Sciences, Makerere University, Kampala, Uganda.ORCID https://orcid.org/0000-0002-6120-1055
Infectious Diseases Institute · UGJohns Hopkins University · USMakerere University · UGUniversity of Cambridge · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Introduction: The evaluation of the patterns of liver injury, derived from liver chemistry panels, often may narrow on probable causes of the liver insult especially when coupled with clinical history, examination, and other diagnostic tests. Methods: Among people living with and without HIV and attending care, we used the Results: Overall, the proportions of participants with cholestatic liver injury, mixed liver injury, and hepatocellular liver injury were 55%, 34%, and 4%, respectively, with similar distribution when stratified by HIV status. Alcohol use among participants without HIV was associated with all patterns of liver injury (cholestatic liver injury (OR = 4.9 CI (1.0-24.2); Conclusions: Liver injury is prevalent among both people living with and without HIV in care, and cholestatic liver injury is the most common pattern. Alcohol is associated with all patterns of liver injury and increasing age associated with cholestatic liver injury among people living without HIV and people living with HIV, respectively.

Identifiers

PMID36748010
PMCPMC9899141
OpenAlexW4318350642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.