Evidence map›Paper›PMID 36748003›Full record

ArticleArXiv2023

Non-contact acoustic micro-tapping optical coherence elastography for quantification of corneal anisotropic elasticity: in vivo rabbit study.

Mitchell A Kirby, Gabriel Regnault, Ivan Pelivanov, Matthew O'Donnell, Ruikang K Wang, Tueng T Shen

Open access · goldAbstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mitchell A KirbyDepartment of Bioengineering, University of Washington, Seattle, Washington 98105, USA.
Gabriel RegnaultDepartment of Bioengineering, University of Washington, Seattle, Washington 98105, USA.
Ivan PelivanovDepartment of Bioengineering, University of Washington, Seattle, Washington 98105, USA.
Matthew O'DonnellDepartment of Bioengineering, University of Washington, Seattle, Washington 98105, USA.
Ruikang K WangDepartment of Bioengineering, University of Washington, Seattle, Washington 98105, USA.
Tueng T ShenSchool of Medicine, University of Washington, Seattle, Washington 98195, USA.
University of Washington · US

Funding

Dynamic OCE with acoustic micro-tapping for in vivo monitoring of skin graft surgeriesR01AR077560 · NIAMS · UNIVERSITY OF WASHINGTON · PI PELIVANOV, IVAN · 2021 to 2025
$3.0M
Optical coherence elastography of corneal dynamicsR01EY026532 · NEI · UNIVERSITY OF WASHINGTON · PI SHEN, TUENG T · 2016 to 2020
$2.9M
Ultra-wide field optical coherence tomography based angiography for imaging diabetic retinopathyR01EY028753 · NEI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2018 to 2021
$2.2M
Sensitive tumor detection with magnetomotive imagingR01CA170734 · NCI · UNIVERSITY OF WASHINGTON · PI GAO, XIAOHU · 2012 to 2015
$1.8M
Non-invasive trapping and imaging of circulating tumor cells in the peripheral vaR01EB016034 · NIBIB · UNIVERSITY OF WASHINGTON · PI O'DONNELL, MATTHEW · 2013 to 2016
$1.7M
NCI NIH HHS R01 CA170734NEI NIH HHS R01 EY026532NEI NIH HHS R01 EY028753NIAMS NIH HHS R01 AR077560NIBIB NIH HHS R01 EB016034
6 · The paper itself

Abstract

purposeTo demonstrate accurate measurement of corneal elastic moduli in vivo with non-contact and non-invasive optical coherence elastography.

methodsElastic properties (in-plane Young's modulus E and both in-plane, u, and out-of-plane, G, shear moduli) of rabbit cornea were quantified in vivo using non-contact dynamic Acoustic micro-Tapping Optical Coherence Elastography (AuT-OCE). The IOP-dependence of measured mechanical properties was explored in extracted whole globes following in vivo measurement. A nearly-incompressible transverse isotropic (NITI) model was used to reconstruct moduli from AuT-OCE data. Independently, cornea elastic moduli were also measured ex vivo with traditional, destructive mechanical tests (tensile extensometry and shear rheometry).

resultsOur study demonstrates strong anisotropy of corneal elasticity in rabbits. The in-plane Young's modulus, computer as E=3u, was in the range of 20-44 MPa, whereas the out-of-plane shear modulus was in the range of 34-261 kPa. Both pressure-dependent ex vivo OCE and destructive mechanical tests performed on the same samples within an hour of euthanasia strongly support the results of AuT-OCE measurements.

conclusionsNon-contact AuT-OCE can non-invasively quantify cornea anisotropic elastic properties in vivo. TRANSLATIONAL RELEVANCE: As OCT is broadly accepted in Ophthalmology, these results suggest the potential for rapid translation of AuT-OCE into clinical practice. In addition, AuT-OCE can likely improve diagnostic criteria of ectatic corneal diseases, leading to early diagnosis, reduced complications, customized surgical treatment, and personalized biomechanical models of the eye.

Identifiers

PMID36748003
PMCPMC9900963
OpenAlexW4319333569

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.