Evidence map›Paper›PMID 36747946›Full record

ReviewHeliyon2023

Hepatitis B virus infection combined with nonalcoholic fatty liver disease: Interaction and prognosis.

Lili Liu, Hong Li, Yang Zhang, Jing Zhang, Zhenhuan Cao

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06589167 (Metabolic Dysfunction Among Egyptian Patients with Chronic HBV), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06589167 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Metabolic Dysfunction Among Egyptian Patients with Chronic HBV

TypeobservationalSponsorAssiut UniversityRan2024 to 2025Enrolled100ConditionsMetabolic Syndrome, Fatty Liver Disease
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Impact of Socio-Economic, Behavioural and Clinical Factors on Liver Disease Progression in Individuals With HIV and Hepatitis B.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lili LiuThe Third Unit, Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Hong LiThe Third Unit, Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Yang ZhangBiomedical Information Center, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Jing ZhangThe Third Unit, Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Zhenhuan CaoThe Third Unit, Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Beijing YouAn Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis B virus (HBV) infection is still one kind of the infectious diseases that seriously threaten human health. Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide. HBV infection complicated with NAFLD is increasingly common. This review mainly describes the interaction between HBV infection and NAFLD, the interaction between steatosis and antiviral drugs, and the prognosis of HBV infection complicated with NAFLD. Most studies suggest that HBV infection may reduce the incidence of NAFLD. NAFLD can promote the spontaneous clearance of hepatitis B surface antigen (HBsAg), but whether it affects antiviral efficacy has been reported inconsistently. HBV infection combined with NAFLD can promote the progression of liver fibrosis, especially in patients with severe steatosis. The outcome of HBV infection combined with NAFLD predisposing to the progression of HCC remains controversial.

Indexed as

aHR, adjusted hazard ratioAntiviral efficacyAVT, antiviral therapyBMI, body mass indexCHB, chronic hepatitis BCI, confidence intervalETV, entecavirHBeAg, hepatitis B e antigenHBsAg, hepatitis B surface antigenHBV, hepatitis B virusHBV infectionHCC, hepatocellular carcinomaHDL-C, high-density lipoprotein-cholesterolHDL, high-density lipoproteinHepatocellular carcinomaHR, hazard ratioHS, hepatis steatosisLDL-C, low-density lipoprotein cholesterolLiver fibrosisNAFLD, nonalcoholic fatty liver diseaseNA, nucleos(t)ide analogueNASH, nonalcoholic steatohepatitisNonalcoholic fatty liver diseasenon-HDL-C, non-high-density lipoprotein-cholesterolNR, not reportedOR, odds ratioPEG-IFN, pegylated interferonTAF, tenofovir alafenamideTDF, tenofovirTLR4, Toll-Like Receptor 4

Identifiers

PMID36747946
PMCPMC9898750
OpenAlexW4317624617

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.