Evidence map›Paper›PMID 36747875›Full record

ArticlebioRxiv : the preprint server for biology2023

Nuclease-dead S.

Danuta Sastre, Faria Zafar, C Alejandra Morato Torres, Desiree Piper, Deniz Kirik, Laurie H Sanders, Stanley Qi, Birgitt Schüle

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Danuta SastreStanford University School of Medicine, Department of Pathology, Stanford, CA 94305, U.S.A.
Faria ZafarStanford University School of Medicine, Department of Pathology, Stanford, CA 94305, U.S.A.
C Alejandra Morato TorresStanford University School of Medicine, Department of Pathology, Stanford, CA 94305, U.S.A.
Desiree PiperSan Jose State University, Department of Biological Sciences, San Jose, 95192 CA, U.S.A.
Deniz KirikDepartment of Experimental Medical Science, Lund University, Lund, Sweden.
Laurie H SandersDepartments of Neurology and Pathology, Duke Center for Neurodegeneration and Neurotherapeutics, Duke University Medical Center, Durham, NC 27710, U.S.A.
Stanley QiStanford University, Department of Bioengineering, Stanford, CA 94305, U.S.A.
Birgitt SchüleStanford University School of Medicine, Department of Pathology, Stanford, CA 94305, U.S.A.
Stanford University · USDuke University · USLund University · SESan Jose State University · US

Funding

Mechanisms of mitochondrial genome integrity in familial and idiopathic Parkinson's diseaseR01NS119528 · NINDS · DUKE UNIVERSITY · PI SANDERS, LAURIE H · 2020 to 2024
$2.9M
NINDS NIH HHS R01 NS119528
6 · The paper itself

Abstract

Parkinson's disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need. A promising target is alpha-synuclein or its aggregated form, which accumulates in the brain of PD patients as Lewy bodies. While it is not entirely clear which alpha-synuclein protein species is disease relevant, mere overexpression of alpha-synuclein in hereditary forms leads to neurodegeneration. To specifically address gene regulation of alpha-synuclein, we developed a CRISPR interference (CRISPRi) system based on the nuclease dead

Indexed as

alpha-synuclein SNCAClustered regularly interspaced short palindromic repeatCRISPRCRISPR interferencegene editinggene regulationisoformKRABKrueppel-associated boxKrueppel domainLewy body diseasenuclease-dead Cas9Parkinson’s diseaseSadCas9S. aureus dCas9synucleinopathytranscription

Identifiers

PMID36747875
PMCPMC9900844
OpenAlexW4317888671

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.