Evidence map›Paper›PMID 36747855›Full record

ArticlebioRxiv : the preprint server for biology2023

Timing of behavioral responding to long-duration Pavlovian fear conditioned cues.

Kristina M Wright, Claire E Kantor, Mahsa Moaddab, Michael A McDannald

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kristina M WrightBoston College, Department of Psychology & Neuroscience, Chestnut Hill, MA 02467.
Claire E KantorBoston College, Department of Psychology & Neuroscience, Chestnut Hill, MA 02467.
Mahsa MoaddabBoston College, Department of Psychology & Neuroscience, Chestnut Hill, MA 02467.
Michael A McDannaldBoston College, Department of Psychology & Neuroscience, Chestnut Hill, MA 02467.

Funding

Early life stress, neuron-type function and a raphe-amygdala circuit for threat estimationR01MH117791 · NIMH · BOSTON COLLEGE · PI MCDANNALD, MICHAEL A · 2018 to 2025
$4.0M
NIMH NIH HHS R01 MH117791
6 · The paper itself

Abstract

Behavioral responding is most beneficial when it reflects event timing. Compared to reward, there are fewer studies on timing of defensive responding. We gave female and male rats Pavlovian fear conditioning over a baseline of reward seeking. Two 100-s cues predicted foot shock at different time points. Rats acquired timing of behavioral responding to both cues. Suppression of reward seeking was minimal at cue onset and maximal before shock delivery. Rats also came to minimize suppres-sion of reward seeking following cue offset. The results reveal timing as a mechanism to focus defen-sive responding to shock-imminent, cue periods.

Identifiers

PMID36747855
PMCPMC9900810

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.