Evidence map›Paper›PMID 36747815›Full record

ArticlebioRxiv : the preprint server for biology2023

Accumulation of TCR signaling from self-antigens in naive CD8 T cells mitigates early responsiveness.

Joel Eggert, Wendy M Zinzow-Kramer, Yuesong Hu, Yuan-Li Tsai, Arthur Weiss, Khalid Salaita, Christopher D Scharer, Byron B Au-Yeung

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joel EggertDivision of Immunology, Lowance Center for Human Immunology, Department of Medicine, Emory University.
Wendy M Zinzow-KramerDivision of Immunology, Lowance Center for Human Immunology, Department of Medicine, Emory University.
Yuesong HuDepartment of Chemistry, Emory University.
Yuan-Li TsaiRosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Departments of Medicine and of Microbiology and Immunology, University of California, San Francisco.
Arthur WeissRosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Departments of Medicine and of Microbiology and Immunology, University of California, San Francisco.
Khalid SalaitaDepartment of Chemistry, Emory University.
Christopher D ScharerDepartment of Microbiology and Immunology, Emory University.
Byron B Au-YeungDivision of Immunology, Lowance Center for Human Immunology, Department of Medicine, Emory University.
Emory University · USUniversity of California, San Francisco · US

Funding

Molecular and Cellular Mechanisms in CancerT32CA108462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2004 to 2024
$10.4M
Regulation of CD4 T cell tolerance by the NR4A family of nuclear receptorsR01AI165706 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JULIE ZIKHERMAN · 2022 to 2026
$3.0M
NCI NIH HHS T32 CA108462NIAID NIH HHS R01 AI165706
6 · The paper itself

Abstract

The cumulative effects of T cell receptor (TCR) signal transduction over extended periods of time influences T cell biology, such as the positive selection of immature thymocytes or the proliferative responses of naive T cells. Naive T cells experience recurrent TCR signaling in response to self-antigens in the steady state. However, how these signals influence the responsiveness of naive CD8

Identifiers

PMID36747815
PMCPMC9900884
OpenAlexW4318406169

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.