ArticlebioRxiv : the preprint server for biology2023
Mis-spliced transcripts generate
Open access · greenAbstract readPreprint
In one paragraph
Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed, 38 citations in OpenAlex.
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Authors and funding
46 authors at 9 institutions in 3 countries.
Sahba SeddighiNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Yue A QiCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.
Anna-Leigh BrownUCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.
Oscar G WilkinsUCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.
Colleen BeredaMedical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Cedric BelairLaboratory of Genetics and Genomics, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Yongjie ZhangDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Mercedes PrudencioDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Matthew J KeussUCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.
Aditya KhandeshiLaboratory of Genetics and Genomics, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Sarah PicklesDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Sarah E HillNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
James HawrotNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Daniel M RamosCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.
Hebao YuanNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Jessica RobertsCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.
Erika Kelmer SacramentoLeibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany.
Syed I ShahData Tecnica International, Washington, DC, USA.
Mike A NallsCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.
Jenn Colon-MercadoNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Joel F ReyesNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Veronica H RyanNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Matthew P NelsonCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.
Casey CookDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Ziyi LiCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.
Laurel ScrevenCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.
Justin Y KwanNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Anantharaman ShantaramanDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Lingyan PingDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Yuka KoikeDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Björn OskarssonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Nathan StaffDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Duc M DuongDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Aisha AhmedUCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.
Maria SecrierDepartment of Genetics, Evolution and Environment, UCL Genetics Institute, UCL, London, UK.
Jerneg UleUCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.
Steven JacobsonNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Jonathan RohrerUCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.
Andrea MalaspinaUCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.
Jonathan D GlassDepartment of Neurology, Center for Neurodegenerative Diseases, Emory University, Atlanta, GA, USA.
Alessandro OriLeibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany.
Nicholas T SeyfriedDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Manolis MaragkakisLaboratory of Genetics and Genomics, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Pietro FrattaUCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.
Michael E WardNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
National Institutes of Health · USJacksonville College · USNational Institute of Neurological Disorders and Stroke · USNational Hospital for Neurology and Neurosurgery · GBEmory University · USLeibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DEInstitute of Genetics and Cancer · GBJohns Hopkins University · USThe Francis Crick Institute · GB
Funding
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MRNA dynamics and co-translational decay in aging and aging-related diseaseZIAAG000696 · NIA · NATIONAL INSTITUTE ON AGING · PI MARAGKAKIS, MANOLIS · 2020 to 2025
$14.0MMedical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4MHuman Biomarkers CoreU54NS123743 · NINDS · STANFORD UNIVERSITY · PI FRATTA, PIETRO, GITLER, AARON D. · 2021 to 2025
$8.2MStathmin-2 and TDP-43 neurodegeneration in Alzheimer’s and multi-etiology dementiasRF1NS120992 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Keith A Josephs, Mercedes Prudencio · 2021 to 2026
$4.2MThe role of neuronal mRNA transport granule packaging in ALS/FTDFI2GM142475 · NIGMS · U.S. NATIONAL INST/NEURO/DS/STROKE · PI RYAN, VERONICA HANLEY · 2021 to 2021
–Medical Research Council MC_PC_MR/S022708/1Medical Research Council MR/S006508/1Medical Research Council MR/W005190/1NIA NIH HHS P01 AG019724NIGMS NIH HHS FI2 GM142475NIGMS NIH HHS T32 GM136577NINDS NIH HHS RF1 NS120992NINDS NIH HHS U54 NS123743
Abstract
Functional loss of TDP-43, an RNA-binding protein genetically and pathologically linked to ALS and FTD, leads to inclusion of cryptic exons in hundreds of transcripts during disease. Cryptic exons can promote degradation of affected transcripts, deleteriously altering cellular function through loss-of-function mechanisms. However, the possibility of
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.