Evidence map›Paper›PMID 36747786›Full record

ArticlebioRxiv : the preprint server for biology2023

Multimodal characterization of antigen-specific CD8

Bingjie Zhang, Rabi Upadhyay, Yuhan Hao, Marie I Samanovic, Ramin S Herati, John Blair, Jordan Axelrad, Mark J Mulligan, Dan R Littman, Rahul Satija

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Bingjie ZhangNew York Genome Center, New York, NY, USA.
Rabi UpadhyayDepartment of Cell Biology and Regenerative Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Yuhan HaoNew York Genome Center, New York, NY, USA.
Marie I SamanovicDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Ramin S HeratiDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
John BlairNew York Genome Center, New York, NY, USA.
Jordan AxelradDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Mark J MulliganDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Dan R LittmanDepartment of Cell Biology and Regenerative Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Rahul SatijaNew York Genome Center, New York, NY, USA.
New York Genome Center · USNYU Langone Health · USHoward Hughes Medical Institute · USNew York University · US

Funding

Virology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI GEORG Michael LAUER · 2009 to 2026
$48.1M
Establishment of the New York University Vaccine and Treatment Evaluation Unit (NYU VTEU) - DMID 21-0012UM1AI148574 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Angelica Cifuentes Kottkamp, Anoma Nellore · 2020 to 2026
$23.9M
Center for Integrated Cellular Analysis - Valeria A. Sanchez EstradaRM1HG011014 · NHGRI · NEW YORK GENOME CENTER · PI LANDAU, DAN, SATIJA, RAHUL · 2020 to 2025
$22.1M
Comprehensive reference atlas construction, geolocation and data integration for HuBMAP HIVE [5 of 5]OT2OD033760 · OD · NEW YORK GENOME CENTER · PI SATIJA, RAHUL · 2022 to 2025
$6.1M
A systems immunology approach for predicting poor responses to Hepatitis B vaccinationR01AI158617 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HERATI, RAMIN · 2021 to 2025
$3.9M
NHGRI NIH HHS RM1 HG011014NIAID NIH HHS R01 AI158617NIAID NIH HHS U19 AI082630NIAID NIH HHS UM1 AI148574NIH HHS OT2 OD033760
6 · The paper itself

Abstract

The human immune response to SARS-CoV-2 antigen after infection or vaccination is defined by the durable production of antibodies and T cells. Population-based monitoring typically focuses on antibody titer, but there is a need for improved characterization and quantification of T cell responses. Here, we utilize multimodal sequencing technologies to perform a longitudinal analysis of circulating human leukocytes collected before and after BNT162b2 immunization. Our data reveal distinct subpopulations of CD8

Identifiers

PMID36747786
PMCPMC9900816
OpenAlexW4317888705

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.